Results 301 to 310 of about 4,801,647 (345)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

L-Ascorbic acid preferentially kills KRAS mutant pancreatic cancer cells through DNA damage. [PDF]

Sci Rep
Jang HL, Kim ST, Hong JY, Jang KT, Heo J, Chon HJ, Park YS, Park JO.   +7 more
europepmc   +1 more source

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

The Yeast HMGB Protein Hmo1 Is a Multifaceted Regulator of DNA Damage Tolerance. [PDF]

Int J Mol Sci
Huo J, Wei A, Guo N, Wang R, Bi X.
europepmc   +1 more source

Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug Bleomycin. [PDF]

Genes Environ
Shimizu N, Izawa K, Washif M, Morozumi R, Hirota K, Tsuda M.   +5 more
europepmc   +1 more source

Targeting the DNA damage response through TBL1X in mantle cell lymphoma. [PDF]

Blood Adv
Pray B, Baiocchi E, Leon S, Barta B, Koirala S, Tsyba L, Hinterschied C, Carvajal-Moreno J, Hout I, Nishat S, Jindal U, Jain N, Singh S, Sehgal L, Chan WK, Hanel W, Yalowich J, Baiocchi RA, Alinari L.   +18 more
europepmc   +1 more source

Targeting DNA Damage Repair to Enhance Antitumor Immunity in Radiotherapy: Mechanisms and Opportunities. [PDF]

Int J Mol Sci
Yang L, Wei W, Yuan X, Guo E, Peng P, Wang J, Sun W.   +6 more
europepmc   +1 more source

Activation of the sympathetic-adrenal-medullary system increases DNA damage during the transition to captivity. [PDF]

Integr Org Biol
Kilgour DAV, Romero LM.
europepmc   +1 more source

Evolutionary Insights into the Length Variation of DNA Damage Response Proteins Across Eukaryotes. [PDF]

Genome Biol Evol
Wiredu-Boakye D, Higgins L, Gahura O, Butenko A, Leonard G, Freeman MA, Kristmundsson Á, Moore K, Harrison JW, Mac Donald S, Yurchenko V, Williams BAP, Chahwan R.   +12 more
europepmc   +1 more source