Results 301 to 310 of about 833,203 (324)
DNA damage response regulator ATR licenses PINK1-mediated mitophagy. [PDF]
Nucleic Acids ResMarx C +15 more
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LDHB silencing enhances the effects of radiotherapy by impairing nucleotide metabolism and promoting persistent DNA damage. [PDF]
Sci RepDeng H +10 more
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Activation and modulation of the host response to DNA damage by an integrative and conjugative element. [PDF]
J BacteriolMcKeithen-Mead S +3 more
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DNA Damage by Fasicularin [PDF]
Journal of the American Chemical Society, 2005 Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Hideki Abe +4 more
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Current Opinion in Cell Biology, 2016
Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Ivan Psakhye, Dana Branzei
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Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Ivan Psakhye, Dana Branzei
openaire +3 more sources
Critical Reviews in Oncology/Hematology, 2020
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent Cetin +2 more
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Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent Cetin +2 more
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Mechanisms of Ageing and Development, 2004
The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Michael R. Lieber, Zarir E Karanjawala
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The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Michael R. Lieber, Zarir E Karanjawala
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DNA Methyltransferases and DNA Damage
2022Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation
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Photochemistry and Photobiology, 1988
Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
Francis P. Gasparro, Regina M. Santella
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Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
Francis P. Gasparro, Regina M. Santella
openaire +3 more sources