Results 301 to 310 of about 1,589,396 (359)

DNA damage and repair in patients with early chronic kidney disease with or without type 2 diabetes. [PDF]

Front Clin Diabetes Healthc
Andrade-Sierra J, Pazarín-Villaseñor L, García-Sánchez A, Cardona-Muñoz EG, Campos-Pérez W, Martínez-López E, Campos-Bayardo TI, Román-Rojas D, Gómez-Hermosillo LF, Casillas-Moreno J, Echavarría R, Díaz-de la Cruz EN, Totsuka-Sutto S, Miranda-Díaz AG.   +13 more
europepmc   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

NSUN2 facilitates DICER cleavage of DNA damage-associated R-loops to promote repair. [PDF]

Nat Commun
Alagia A, Ajit K, Di Fazio A, Long Q, Gullerova M.   +4 more
europepmc   +1 more source

Nationwide Characterization of MFN2‐Related CMT in 176 Japanese Patients: Clinical and Genetic Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Mitofusin 2 (MFN2) is a major causative gene for axonal Charcot – Marie – Tooth disease type 2A (CMT2A), with a wide phenotypic spectrum. Comprehensive large ‐ scale genotype – phenotype association studies are essential for understanding disease pathogenesis and improved clinical management.
Masahiro Ando, Yujiro Higuchi, Jun‐Hui Yuan, Akiko Yoshimura, Chikashi Yano, Takahiro Hobara, Fumikazu Kojima, Yu Hiramatsu, Satoshi Nozuma, Tomonori Nakamura, Yusuke Sakiyama, Jun Mitsui, Shoji Tsuji, Hiroshi Takashima   +13 more
wiley   +1 more source

Targeting MAT2A synergistically induces DNA damage in osteosarcoma cells through EZH2-mediated H3K27me3 modification. [PDF]

J Orthop Translat
Yang B, Wang H, Tao Y, Yang X, Mu H, Yang L, Jiang Y, Wang Z, Zhang R, Cai Z, Yang C, Zuo D, Hua Y, Sun W.   +13 more
europepmc   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

DNA damage response pathway regulates Nrf2 in response to oxidative stress. [PDF]

Sci Adv
Jiang XY, Guo QQ, Wang SS, Guo R, Zou Y, Liu JW, Feng YL, Guo Y, Li YH, Liu XY, Zhang XY, Hao S, Wu XX, Li MH, Liu A, Li CL, Guo WD, Xu HD, Song XY, Finkel T, Cao L.   +20 more
europepmc   +1 more source

RAB39B Related Parkinsonism in an Italian Family: A Unique Use of Advanced Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Parkinson's disease (PD) is a neurodegenerative disorder that may sometimes be caused by deleterious genetic variants. Among them, RAB39B polymorphisms are known as rare causes of early‐onset PD associated with intellectual disability (Waisman's syndrome).
Caterina Del Regno, Giovanni Ermanis, Christian Lettieri, Andrea Bernardini, Gaia Pellitteri, Enrico Belgrado, Elena Betto, Gian Luigi Gigli, David De Monte, Marco Domenico Scanni, Marco Mucchiut, Giuseppe Damante, Mariarosaria Valente, Francesco Janes   +13 more
wiley   +1 more source

Mechanisms of DNA Damage Recognition by UDG and PARP1 in the Nucleosome. [PDF]

Biomolecules
Ghediri S, Sarma PAP, Saravanan V, Abbadie C, Blossey R, Cleri F.   +5 more
europepmc   +1 more source

WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer. [PDF]

EMBO J
Sobajima T, Fulcher LJ, Batley C, Alsop SJ, Veakins J, Barr FA.   +5 more
europepmc   +1 more source