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DNA damage, repair and chromosomal damage
International Journal of Radiation Biology, 1997An important question in radiobiology is the relationship between primary DNA damage and chromosomal aberrations. What determines the chromosomal aberration frequency, especially in radiosensitive cells? Much evidence points to the double-strand break (dsb) as the critical lesion, however there is controversy over whether it is the initial induction ...
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Blood
Abstract DNA-damaging agents have represented the first effective treatment for the blood cancer multiple myeloma, and after 65 years since their introduction to the clinic, they remain one of the mainstay therapies for this disease. Myeloma is a cancer of plasma cells.
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Abstract DNA-damaging agents have represented the first effective treatment for the blood cancer multiple myeloma, and after 65 years since their introduction to the clinic, they remain one of the mainstay therapies for this disease. Myeloma is a cancer of plasma cells.
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New England Journal of Medicine, 2009
NA damage has emerged as a major culprit in cancer and many diseases related to aging. The stability of the genome is supported by an intricate machinery of repair, damage tolerance, and checkpoint pathways that counteracts DNA damage. In addition, DNA damage and other stresses can trigger a highly conserved, anticancer, antiaging survival response ...
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NA damage has emerged as a major culprit in cancer and many diseases related to aging. The stability of the genome is supported by an intricate machinery of repair, damage tolerance, and checkpoint pathways that counteracts DNA damage. In addition, DNA damage and other stresses can trigger a highly conserved, anticancer, antiaging survival response ...
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Circulating Tumor DNA in Advanced Solid Tumors: Clinical Relevance and Future Directions
Ca-A Cancer Journal for Clinicians, 2021Heather Parsons +2 more
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DNA Damage and Repair in Age-Related Inflammation
Nature Reviews Immunology, 2023Vera Gorbunova +2 more
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