Results 271 to 280 of about 1,590,914 (306)
Some of the next articles are maybe not open access.
Mechanisms of Ageing and Development, 2004
The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Zarir E, Karanjawala, Michael R, Lieber
openaire +2 more sources
The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Zarir E, Karanjawala, Michael R, Lieber
openaire +2 more sources
Chloramphenicol damages bacterial DNA
Biochemical and Biophysical Research Communications, 1977L(+)-threo-chloramphenicol induces reversion of His−Salmonella typhimurium strains TA100 and TA1535 in the conventional Ames' assay without microsomal activation. Any mutagenicity of D(−)-threo-chloramphenicol was masked by toxicity. Similarly, a sensitive fluctuation test showed mutagenesis with L(+)-threo-chloramphenicol at concentrations of 0.5 μM ...
S F, Jackson +3 more
openaire +2 more sources
Repairing DNA-methylation damage
Nature Reviews Molecular Cell Biology, 2004Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism.
openaire +2 more sources
1991
Most organisms can respond to changes in the environment by the induction of a variety of different genes. For example, exposure to elevated temperature, heat shock, leads to the increased transcription (induction) of a number of genes whose protein products, the heat-shock proteins (hsp*), may increase the cellular resistance to heat shock.
M A, Papathanasiou, A J, Fornace
openaire +2 more sources
Most organisms can respond to changes in the environment by the induction of a variety of different genes. For example, exposure to elevated temperature, heat shock, leads to the increased transcription (induction) of a number of genes whose protein products, the heat-shock proteins (hsp*), may increase the cellular resistance to heat shock.
M A, Papathanasiou, A J, Fornace
openaire +2 more sources
Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
exaly
Blood
Abstract DNA-damaging agents have represented the first effective treatment for the blood cancer multiple myeloma, and after 65 years since their introduction to the clinic, they remain one of the mainstay therapies for this disease. Myeloma is a cancer of plasma cells.
openaire +2 more sources
Abstract DNA-damaging agents have represented the first effective treatment for the blood cancer multiple myeloma, and after 65 years since their introduction to the clinic, they remain one of the mainstay therapies for this disease. Myeloma is a cancer of plasma cells.
openaire +2 more sources
DNA damage and repair in age-related inflammation
Nature Reviews Immunology, 2022Yang Zhao +2 more
exaly