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The telomeric DNA damage response as a therapeutic target in idiopathic pulmonary fibrosis. [PDF]

EMBO Mol Med
Rossiello F, Cicio G, Sepe S, Mancheno-Ferris A, Cancila V, Castellini A, Rey F, Bertolazzi G, Oppezzo A, Marinelli E, Cabrini M, di Lillo A, Tavella S, Rosso I, Buffa FM, Tripodo C, d'Adda di Fagagna F.   +16 more
europepmc   +1 more source

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DNA Methyltransferases and DNA Damage

2022
Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation
openaire   +2 more sources

DNA Damage by Fasicularin

Journal of the American Chemical Society, 2005
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Sanjay, Dutta, Hideki, Abe, Sakae, Aoyagi, Chihiro, Kibayashi, Kent S, Gates   +4 more
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DNA damage and aging

Mechanisms of Ageing and Development, 2004
The hypothesis discussed here is that a major component of aging in metazoans is oxidative damage to nuclear DNA. Such a viewpoint would be consistent with the fact that all of the thus far identified premature aging syndromes in mammals involve mutations in nuclear proteins.
Zarir E, Karanjawala, Michael R, Lieber
openaire   +2 more sources