Results 261 to 270 of about 1,590,914 (306)
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Active DNA demethylation damages DNA
Science, 2022Active DNA demethylation maintains enhancer activity in nonproliferating cells but can damage ...
Isaac F, López-Moyado, Anjana, Rao
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Current Opinion in Cell Biology, 2016
Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Dana, Branzei, Ivan, Psakhye
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Accurate chromosomal DNA replication is fundamental for optimal cellular function and genome integrity. Replication perturbations activate DNA damage tolerance pathways, which are crucial to complete genome duplication as well as to prevent formation of deleterious double strand breaks.
Dana, Branzei, Ivan, Psakhye
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DNA Methyltransferases and DNA Damage
2022Ever since the discovery of depletion of CG sites in mammalian genomes it has been clear that cytosine DNA methyltransferases (DNMTs) are linked to the rate at which mutations accumulate in DNA. Research in the intervening decades has shown that DNMTs influence mutation rates through the indirect consequences of methylation on the mechanism of mutation
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DNA damage, repair and chromosomal damage
International Journal of Radiation Biology, 1997An important question in radiobiology is the relationship between primary DNA damage and chromosomal aberrations. What determines the chromosomal aberration frequency, especially in radiosensitive cells? Much evidence points to the double-strand break (dsb) as the critical lesion, however there is controversy over whether it is the initial induction ...
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Journal of the American Chemical Society, 2005
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Sanjay, Dutta +4 more
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Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5'-32P-labeled DNA duplex with fasicularin in pH 7.0 ...
Sanjay, Dutta +4 more
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Photochemistry and Photobiology, 1988
Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
F P, Gasparro, R M, Santella
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Abstract— The direct photomodification of DNA by ultraviolet light or the photo‐induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes.
F P, Gasparro, R M, Santella
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Critical Reviews in Oncology/Hematology, 2020
Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent, Cetin +2 more
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Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme that plays a critical role in the repair of single-strand DNA damage via the base excision repair pathway. PARP inhibitors have substantial single-agent antitumor activity by inducing synthetic lethality.
Bulent, Cetin +2 more
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DNA Damage and Polyploidization
2010A growing body of evidence indicates that polyploidization triggers chromosomal instability and contributes to tumorigenesis. DNA damage is increasingly being recognized for its roles in promoting polyploidization. Although elegant mechanisms known as the DNA damage checkpoints are responsible for halting the cell cycle after DNA damage, agents that ...
Chow, Jeremy Pak Hong +1 more
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Nature Reviews Molecular Cell Biology, 2021
Unexpected high levels of recurrent DNA single-strand break repair were detected in enhancer regions of post-mitotic neurons.
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Unexpected high levels of recurrent DNA single-strand break repair were detected in enhancer regions of post-mitotic neurons.
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