Results 41 to 50 of about 5,360,965 (412)
Track structure simulation of low energy electron damage to DNA using Geant4-DNA [PDF]
Biomedical Physics & Engineering Express 4 (2018) 065009, 2018 Due to the physical and chemical processes that are involved, interactions of ionizing radiations with cells lead to single- and double-strand breaks (SSB and DSB) and base damage to DNA cells. The damage may kill the cells or may be mis-repaired and lead to genetic diseases and cancers. Track structure Monte Carlo simulation of the DNA damage provides
arxiv +1 more source
Interplay of space radiation and microgravity in DNA damage and DNA damage response [PDF]
, 2017 In space, multiple unique environmental factors, particularly microgravity and space radiation, pose constant threat to the DNA integrity of living organisms.
Lu, Tao +4 more
core +2 more sources
Tau affects P53 function and cell fate during the DNA damage response [PDF]
Communications Biology 3, 245 (2020), 2020 Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and ...
arxiv +1 more source
Simulation of DNA damage using Geant4-DNA: an overview of the "molecularDNA" example application [PDF]
Prec.Radiat.Oncol. (2023) 1- 11, 2022 The scientific community shows a great interest in the study of DNA damage induction, DNA damage repair and the biological effects on cells and cellular systems after exposure to ionizing radiation. Several in-silico methods have been proposed so far to study these mechanisms using Monte Carlo simulations.
arxiv +1 more source
Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]
, 2019 Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister +77 more
core +1 more source
FEBS Open Bio, 2019 Receptor‐type protein tyrosine phosphatase κ (PTPRK) is considered to be a candidate tumor suppressor. PTPRK dephosphorylates CD133, which is a stem cell marker; phosphorylated CD133 accelerates xenograft tumor growth of colon cancer cells through the ...
Masashi Matsushita +10 more
doaj +1 more source
Replication stress and chromatin context link ATM activation to a role in DNA replication [PDF]
, 2013 ATM-mediated signaling in response to DNA damage is a barrier to tumorigenesis. Here we asked whether replication stress could also contribute to ATM signaling.
Anbalagan, Selvakumar +7 more
core +1 more source
Molecules, 2020 Mitochondria emerged from bacterial ancestors during endosymbiosis and are crucial for cellular processes such as energy production and homeostasis, stress responses, cell survival, and more.
Karolina Boguszewska +3 more
doaj +1 more source
RNase H enables efficient repair of R-loop induced DNA damage. [PDF]
, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core +1 more source
DNA Damage/Repair Management in Cancers
Cancers, 2020 DNA damage is well recognized as a critical factor in cancer development and progression. DNA lesions create an abnormal nucleotide or nucleotide fragment, causing a break in one or both chains of the DNA strand.
Jehad F Alhmoud +3 more
semanticscholar +1 more source