Results 71 to 80 of about 5,360,965 (412)

Two-color spectroscopy of UV excited ssDNA complex with a single-wall nanotube probe: Fast nucleobase autoionization mechanism [PDF]

Nano Research 9, 571-583 (2015), 2015
DNA autoionization is a fundamental process wherein UV-photoexcited nucleobases dissipate energy by charge transfer to the environment without undergoing chemical damage. Here, single-wall carbon nanotubes (SWNT) are explored as a photoluminescent reporter for studying the mechanism and rates of DNA autoionization.
arxiv   +1 more source

Reverse engineering of drug induced DNA damage response signalling pathway reveals dual outcomes of ATM kinase inhibition [PDF]

, 2013
The DNA Damage Response (DDR) pathway represents a signalling mechanism that is activated in eukaryotic cells following DNA damage and comprises of proteins involved in DNA damage detection, DNA repair, cell cycle arrest and apoptosis.
Bown, James L., Idowu, Michael A., Khalil, Hilal S., Zhelev, Nikolai   +3 more
core   +2 more sources

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

Journal of Experimental Medicine, 2018
The cGAS–cGAMP–STING pathway mediates immune and inflammatory responses to cytosolic DNA. This review summarizes recent findings on how genomic instability leads to cGAS activation and how this pathway critically connects DNA damage to autoinflammatory ...
Tuo Li, Zhijian J. Chen
semanticscholar   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Autophagy in DNA Damage Response [PDF]

, 2015
DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska, Janusz Blasiak, Jolanta Bialkowska-Warzecha, Kai Kaarniranta, Piotr Czarny   +4 more
core   +2 more sources

A Genetic Map of the Response to DNA Damage in Human Cells

Cell, 2019
The response to DNA damage is critical for cellular homeostasis, tumor suppression, immunity and gametogenesis. In order to provide an unbiased and global view of the DNA damage response in human cells, we undertook 28 CRISPR/Cas9 screens against 25 ...
Michele Olivieri, Michele Olivieri, Tiffany Cho, Tiffany Cho, Alejandro Álvarez-Quilón, Kejiao Li, M. Schellenberg, Michal Zimmermann, Nicole Hustedt, S. Rossi, Salomé Adam, Henrique Melo, A. Heijink, Guillermo Sastre-Moreno, N. Moatti, R. Szilard, Andrea McEwan, Alexanda K. Ling, Almudena Serrano-Benitez, T. Ubhi, Sumin Feng, J. Pawling, Irene Delgado-Sainz, Michael W. Ferguson, J. Dennis, J. Dennis, Grant W. Brown, Felipe Cortés-Ledesma, R. S. Williams, Alberto Martin, Dongyi Xu, D. Durocher, D. Durocher   +32 more
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

eLife, 2019
Coordination of the cellular response to DNA damage is organised by multi-domain ‘scaffold’ proteins, including 53BP1 and TOPBP1, which recognise post-translational modifications such as phosphorylation, methylation and ubiquitylation on other proteins ...
Nicolas Bigot, Matthew Day, Robert A Baldock, Felicity Z Watts, Antony W Oliver, Laurence H Pearl   +5 more
doaj   +1 more source

The 2Ih and ^OXOG Proximity Consequences on Charge Transfer through ds-DNA: Theoretical Studies of Clustered DNA Damage

Molecules, 2023
Genetic information is continuously exposed to harmful factors, both intra- and extracellular. Their activity can lead to the formation of different types of DNA damage. Clustered lesions (CDL) are problematic for DNA repair systems.
Boleslaw T. Karwowski
doaj   +1 more source

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. [PDF]

, 2011
BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks
A Chicheportiche, A Jazayeri, A Moumen, A Sancar, Abdeladim Moumen, C Zhou, CL Brooks, E Drakos, EP Rogakou, H Zhao, HH Li, Jane M Valentine, JG Jackson, JS Myers, K Oda, KH Vousden, L Chen, LT Vassilev, M Hollstein, MW Jackson, NH Chehab, O Fernandez-Capetillo, P Secchiero, Q Cheng, R Maya, R Verma, RL Warters, S Herold, Sonia Kumar, T Thompson, T Unger, T Unger, TR Shirangi, V Tergaonkar, X Cai   +34 more
core   +3 more sources