Results 91 to 100 of about 3,692,549 (295)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Recruitment kinetics of DNA repair proteins Mdc1 and Rad52 but not 53BP1 depend on damage complexity. [PDF]

, 2012
The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation.
Hilmar Strickfaden (148181), Guenther Dollinger, Brüning, Tino, Anja Derer, Judith Seel (148178), Volker Hable, Derer, Anja, Guido A Drexler, Burgdorf, Christian, Tino Brüning, Drexler, Guido A., Dollinger, Günther, Friedl, Anna A., Christoph Greubel, Greubel, Christoph, Thomas Cremer, Christian Burgdorf, Guido A. Drexler (148161), Christian Burgdorf (148169), Hable, Volker, Tino Brüning (148165), Hilmar Strickfaden, Judith Seel, Christoph Greubel (148173), Thomas Cremer (93), Günther Dollinger (148186), Anna A Friedl, Cremer, Thomas, Guido A. Drexler, Anna A. Friedl, Anja Derer (148175), Strickfaden, Hilmar, Günther Dollinger, Anna A. Friedl (148183), Seel, Judith, Volker Hable (148157)   +35 more
core   +2 more sources

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2BGlu2

Nature Communications, 2016
Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the ...
Gabrielle J. Grundy, Luis M. Polo, Zhihong Zeng, Stuart L. Rulten, Nicolas C. Hoch, Pathompong Paomephan, Yingqi Xu, Steve M. Sweet, Alan W. Thorne, Antony W. Oliver, Steve J. Matthews, Laurence H. Pearl, Keith W. Caldecott   +12 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse

EMBO Reports
Poly(ADP-ribosyl)ation (PARylation) is a transient post-translational modification catalyzed by PARP enzymes and reversed by PARG. PARG inhibition causes sustained PARylation and is being explored as an anticancer strategy, but its cellular consequences ...
Alexandra Mihuț, Debanjan Ghosh, Adrián Kószó, Dávid Szüts, Sarka Andrs Salajkova, Martin Andrs, Jana Dobrovolna, Roberta Fajka-Boja, Gyula Timinszky   +8 more
doaj   +1 more source

Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts

Journal of Nucleic Acids, 2010
DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
doaj   +1 more source

Human checkpoint proteins hRad9, hHus1, and hRad1 form a DNA damage-responsive complex [PDF]

, 2004
Human cells have evolved protective mechanisms such as DNA repair and cell cycle checkpoints in order to promote stability of the genome. Studies on hereditary instability syndromes associated with a higher incidence of malignancies like Xeroderma ...
Volkmer, Elias
core   +1 more source

Lead-induced DNA damage in Vicia faba root cells: Potential involvement of oxidative stress [PDF]

, 2011
Genotoxic effects of lead (0–20 µM) were investigated in whole-plant roots of Vicia faba L., grown hydroponically under controlled conditions. Lead-induced DNA damage in V.
Jean, Séverine, Eric Pinelli, Silvestre, Jérôme, Séverine Jean, Pinelli, Eric, Pourrut, Bertrand, Bertrand Pourrut, Jérôme Silvestre   +7 more
core   +1 more source