Results 111 to 120 of about 3,692,549 (295)

Synergistic Genotoxic Effects of Gamma Rays and UVB Radiation on Human Blood

Antioxidants
Exposure to ionizing and non-ionizing radiation from environmental and clinical settings can significantly threaten genomic stability, especially when combined.
Angeliki Gkikoudi, Athanasia Adamopoulou, Despoina Diamadaki, Panagiotis Matsades, Ioannis Tzakakos, Sotiria Triantopoulou, Spyridon N. Vasilopoulos, Gina Manda, Georgia I. Terzoudi, Alexandros G. Georgakilas   +9 more
doaj   +1 more source

The involvement of single-stranded DNA, replication protein A, and the DNA double-strand break dose in the damage checkpoint of Saccharomyces cerevisiae. [PDF]

, 2007
In response to DNA damage, eukaryotic cells activate a checkpoint signalling cascade, resulting in cell cycle arrest, stabilisation of replication forks and activation of repair.
Zierhut, C.
core  

Drosophila RecQ4 Is Directly Involved in Both DNA Replication and the Response to UV Damage in S2 Cells. [PDF]

, 2012
The RecQ4 protein shows homology to both the S.cerevisiae DNA replication protein Sld2 and the DNA repair related RecQ helicases. Experimental data also suggest replication and repair functions for RecQ4, but the precise details of its involvement remain
Miyata Seiji, Isabelle Crevel, Seiji Miyata, Vo, N, Gilles Crevel (33987), Vo Nicole, Cotterill, S, Isabelle Crevel (119003), Miyata, S, Sue Cotterill (33993), Hoa, L, Lily Hoa (119009), Crevel Isabelle, Hamid Sana, Nicole Vo (119001), Hoa Lily, Cotterill Sue, Sana Hamid, Crevel Gilles, Crevel, G, Crevel, I, Lily Hoa, Nicole Vo, Gilles Crevel, Sana Hamid (119006), Hamid, S, Sue Cotterill, Seiji Miyata (119012)   +27 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

P1327: INHIBITING TELOMERIC DNA DAMAGE RESPONSE AS A NEW THERAPEUTIC STRATEGY TO REJUVENATE THE AGEING HEMATOPOIETIC SYSTEM

HemaSphere, 2023
Alessia Oppezzo, Sara Sepe, Francesca Rossiello, Anastasia Conti, Eugenia Marinelli, Sara Boggio, Alessia DI Lillo, Ilaria Rosso, Sara Tavella, Valentina Matti, Giada Cicio, Valeria Cancila, Alexandra Mancheno-Ferris, Giorgio Bertolazzi, Fabio Iannelli, Raffaella DI Micco, Claudio Tripodo, Fabrizio D’adda DI Fagagna   +17 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Influence of (5′R)- and (5′S)-5′,8-Cyclo-2′-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System’s Nightmare

Cells, 2019
DNA lesions are formed continuously in each living cell as a result of environmental factors, ionisation radiation, metabolic processes, etc. Most lesions are removed from the genome by the base excision repair system (BER).
Bolesław T. Karwowski
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells. [PDF]

FEBS Open Bio
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Ueno Y, Yamazaki S, Hoshina H, Harata M.
europepmc   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

TARG1 affects EGFR signaling through the regulation of RNA metabolism

Scientific Reports
Epidermal Growth Factor Receptor (EGFR) signaling plays a central role in cell proliferation, migration, and survival. Emerging evidence suggests a connection between ADP-ribosylation and EGFR regulation.
Mihály Mérey, Roberta Fajka-Boja, Gergely Imre, Péter Gudmann, Zsolt Török, Lajos Mátés, Ágnes Czibula, Gyula Timinszky   +7 more
doaj   +1 more source