Results 81 to 90 of about 1,589,396 (359)
Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays
STAR Protocols, 2021 Summary: Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow and supply blood cells. Efficient methods for isolation of HSPCs are required. Here, we present protocols for the isolation of human and murine HSPCs using manual and FACS-
Alfredo Rodríguez +5 more
doaj +1 more source
, 2004 Author(s): Guliaev, Anton B.; Singer, B. | Abstract: Alkylation is the reaction of electrophilic chemical compounds or alkylating agents with the nucleophilic centers in organic macromolecules. Alkylating agents include a large variety of chemicals, some of which are potent mutagens or carcinogens.
Guliaev, Anton B., Singer, B.
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DNA damage and tumorigenesis [PDF]
Journal of Molecular Cell Biology, 2013 Asacomplexpathologicprocess,tumorigenesishas involvedvariousregulatingmechanismsatmolecular and cellular levels, particularly tightly related to DNA damage. In previous issues of JMCB, we have published several papers highlighting the relationship between tumorigenesis and DNA damage.
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A working model for cytoplasmic assembly of H/ACA snoRNPs
FEBS Letters, EarlyView.Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2018 The interaction of chemical and physical agents with genetic material can lead to almost 80 different DNA damage formations. The targeted intentional DNA damage by radiotherapy or chemotherapy is a front-line anticancer therapy. An interstrand cross-link
Boleslaw T. Karwowski
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Bioinformatic approaches to the investigation of the atavistic genes implicated in cancer
Frontiers in Bioscience-Landmark, 2021 Introduction: Cancer is a widespread phenomenon occurring across multicellular organisms and represents a condition of atavism, wherein cells follow a path of reverse evolution that unlocks a toolkit of ancient pre-existing adaptations by disturbing hub ...
Aikaterini Louka +3 more
doaj +1 more source
Nature, 2003 The aesthetic appeal of the DNA double helix initially hindered notions of DNA mutation and repair, which would necessarily interfere with its pristine state. But it has since been recognized that DNA is subject to continuous damage and the cell has an arsenal of ways of responding to such injury.
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Ribonucleotide triggered DNA damage and RNA-DNA damage responses [PDF]
RNA Biology, 2014 Research indicates that the transient contamination of DNA with ribonucleotides exceeds all other known types of DNA damage combined. The consequences of ribose incorporation into DNA, and the identity of protein factors operating in this RNA-DNA realm to protect genomic integrity from RNA-triggered events are emerging. Left unrepaired, the presence of
Bret D. Wallace, R. Scott Williams
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FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Comparison of the effectiveness of chlorine, ozone, and photocatalytic disinfection in reducing the risk of antibiotic resistance pollution [PDF]
, 2011 Effectiveness of conventional chlorine and ozone disinfection on reduction of antibiotic resistance was compared with less commonly applied heterogeneous photocatalytic process.
Balcioglu, Isil Akmehmet +5 more
core +1 more source