Results 101 to 110 of about 976,559 (349)

Mfd Protects Against Oxidative Stress in Bacillus Subtilis Independently of its Canonical Function in DNA Repair [PDF]

, 2019
Background: Previous reports showed that mutagenesis in nutrient-limiting conditions is dependent on Mfd in Bacillus subtilis. Mfd initiates one type of transcription-coupled repair (TCR); this type of repair is known to target bulky lesions, like those ...
Contreras, Natalie, Ermi, Tatiana, Martin, Holly Anne, Pedraza-Reyes, Mario, Porter, Katelyne E., Robleto, Eduardo, Vallin, Carmen   +6 more
core   +5 more sources

Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity

OncoTarget, 2017
Patients with human papillomavirus type 16 (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCC) display increased sensitivity to radiotherapy and improved survival rates in comparison to HPV-negative forms of the disease.
Catherine M. Nickson, Parisa Moori, R. Carter, C. Rubbi, J. Parsons   +4 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

TopBP1 utilises a bipartite GINS binding mode to support genome replication

Nature Communications
Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance.
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos   +13 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genetic damage and potential mechanism exploration under different air pollution patterns by multi-omics

Environment International, 2022
Ambient air pollution was classified as carcinogenic to humans (Group 1) for lung cancer. DNA damage was an important first step in the process of carcinogenesis, and could also be induced by air pollution.
Jiayu Xu, Qiaojian Zhang, Zekang Su, Yu Liu, Tenglong Yan, Yali Zhang, Tiancheng Wang, Xuetao Wei, Zhangjian Chen, Guiping Hu, Tian Chen, Guang Jia   +11 more
doaj   +1 more source

CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway. [PDF]

, 2020
With its high efficiency for site-specific genome editing and easy manipulation, the clustered regularly interspaced short palindromic repeats (CRISPR)/ CRISPR associated protein 9 (CAS9) system has become the most widely used gene editing technology in ...
Chen, Qu, Fu, Xuemei, Kim, Jinchul, Liu, Jingfeng, Tang, Qingshuang, Xu, Shuxiang, Xu, Yang   +6 more
core  

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]

, 2019
Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister, Beadle, Belin, Bennett, Britton, Buxboim, Charlotte R. Pfeifer, Cho, Cornelius, Cumming, Dazhen Liu, Denais, Dennis E. Discher, Dong, Duheron, Emily J. Chen, Frigault, Garay, Giese, Gomes, Grundy, Harada, Harding, Hatch, Houtgraaf, Imlay, Irena L. Ivanovska, Irianto, Irianto, Ivkovic, Jerome Irianto, Kalia Pannell, Khatau, Kryston, Kuangzheng Zhu, Lawrence J. Dooling, Lee, Liu, Liu, Lu, Lucas R. Smith, López-Bigas, Maciejowski, Mahaseth, Mai Wang, Mavrakis, Mello Filho, Michael P. Tobin, Mogilner, Morita, Pajerowski, Pathak, Petrie, Pfeifer, Pfeifer, Raab, Raab, Radisky, Rancati, Rice, Rico, Rizvi, Roger A. Greenberg, Sancar, Skamagki, Strano, Stroka, Surcel, Takaki, Thiam, Thomas, Turgay, Wang, Wolf, Xia, Yan, Yuntao Xia, Zhang   +77 more
core   +1 more source

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates to maintain genome stability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation ...
María Fernández-Casañas, Eleftheria Karanika, Umit Aliyaskarova, Tomisin Olukoga, Alex D. Herbert, Antony W. Oliver, Matthew Day, Adrijana Crncec, Kok-Lung Chan   +8 more
doaj   +1 more source

Radiation induced DNA damage responses [PDF]

, 2006
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links.
Jeggo, Penny, Löbrich, Markus
core   +1 more source