Results 121 to 130 of about 1,030,824 (346)

BRIT1/MCPH1 links chromatin remodelling to DNA damage response [PDF]

, 2009
To detect and repair damaged DNA, DNA damage response proteins need to overcome the barrier of condensed chromatin to gain access to DNA lesions1. ATP-dependent chromatin remodeling is one of the fundamental mechanisms used by cells to relax chromatin in
AA Goodarzi, AA Sartori, AJ Morrison, AJ Pierce, Andrew P. Jackson, AP Jackson, B Chai, CL Peterson, CWM Roberts, Eun-Kyoung Yim, GJ Narlikar, GK Alderton, Guang Peng, H van Attikum, Hui Dai, Ineke van der Burgt, J Chen, JA Martens, JH Park, JL Wood, JL Wood, K Nakanishi, Kaiyi Li, L Zou, LA Boyer, Mei-Ren Pan, ML Phelan, MR Lieber, P Sung, R Rai, R Scully, Ruozhen Hu, S Matsuoka, Shiaw-Yih Lin, SY Lin, SY Lin, T Tsukuda, TK Pandita, U Rass, X Xu, X Yu, Y Ziv   +41 more
core   +2 more sources

Sirtuins and DNA damage repair: SIRT7 comes to play

The Nucleus, 2017
Aging is characterized by a cumulative loss of genome integrity, which involves chromatin reorganization, transcriptional dysregulation and the accumulation of DNA damage.
B. Vazquez, Joshua K. Thackray, Lourdes Serrano   +2 more
semanticscholar   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Targeting ATM pathway for therapeutic intervention in cancer [PDF]

, 2012
The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan, Khalil, Hilal S., Lane, David P., Tummala, Hemanth, Zhelev, Nikolai   +4 more
core   +3 more sources

The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer

OncoTarget, 2016
The stability and integrity of the human genome are maintained by the DNA damage repair (DDR) system. Unrepaired DNA damage is a major source of potentially mutagenic lesions that drive carcinogenesis. In addition to gene mutation, DNA methylation occurs
Dan Gao, J. Herman, M. Guo
semanticscholar   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Exploring DNA Damage and Repair Mechanisms: A Review with Computational Insights

BioTech
DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders.
Jiawei Chen, Ravi Potlapalli, Heng Quan, Lingtao Chen, Ying Xie, Seyedamin Pouriyeh, Nazmus Sakib, Lichao Liu, Yixin Xie   +8 more
doaj   +1 more source

New Mechanisms of DNA Repair Defects in Fused in Sarcoma–Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?

Journal of Experimental Neuroscience, 2019
Genome damage and defective DNA repair are etiologically linked to several neurodegenerative disorders, including fused in sarcoma (FUS)–associated amyotrophic lateral sclerosis (ALS).
Haibo Wang, Muralidhar L Hegde
doaj   +1 more source

Fertilization capacity with rainbow trout DNA-damaged sperm and embryo developmental success [PDF]

, 2010
Mammalian spermatozoa undergo a strong selection process along the female tract to guarantee fertilization by good quality cells, but risks of fertilization with DNA-damaged spermatozoa have been reported.
Ahmadi, Andrabi, Barroso, Baumber, Beirao, Cabrita, Evenson, Flajshans, Fortier, Hakem, Hales, Holt, Hu, Irvine, J Beirão, Jalabert, Jaroudi, Lee, Li, Liao, M P Herráez, Maluszynska, Matsuda, S Martínez-Páramo, S Pérez-Cerezales, Satake, Schulte, Singh, Sun, Tam, Tarin, Yeates   +31 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source