Results 121 to 130 of about 752,369 (314)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The involvement of single-stranded DNA, replication protein A, and the DNA double-strand break dose in the damage checkpoint of Saccharomyces cerevisiae.

, 2007
In response to DNA damage, eukaryotic cells activate a checkpoint signalling cascade, resulting in cell cycle arrest, stabilisation of replication forks and activation of repair.
Zierhut, C.
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Role and Regulation of CIEBPa in Response to DNA Damage

, 2009
C/EBPa and C/EBPβ are members of basic leucine zipper (bZIP) class of transcription factors. They are abundantly expressed in epidermis. C/EBPa expression is diminished in mouse and human squamous cell as well as basal cell carcinomas.
Ranjan, Rakesh
core  

Responses of hyperthermophilic crenarchaea to UV irradiation

, 2007
This work was supported by a dedicated functional genomics grant from the Swedish Research Council and the Swedish Graduate Research School in Genomics and Bioinformatics to RB, and by grants from the Wellcome Trust and BBSRC to MFW.Background: DNA ...
Lundgren, Magnus,, Munro, Stacey, Gotz, Dorothee, White, Malcolm F., Magnus Lundgren, Stacey Munro, Rolf Bernander, Lundgren, Magnus, Sonia Paytubi, Malcolm F White, Dorothee Götz, Bernander, Rolf,, Paytubi, Sonia, White, Malcolm F.,, Bernander, Rolf   +14 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ATM-dependent and -independent Chk2 phosphorylation, activation and cell cycle regulation in response to DNA damage

, 2000
The highly conserved Chk2 kinase has a key role in delaying the cell cycle progression in response to DNA damage in eukaryotic cells. Using human lymphoblastoid and fibroblast cell lines we have characterized the time-dependent Chk2 phosphorylation ...
G. Buscemi, M. Nakanishi, S. Mizutani, L. Chessa, L. Zannini, D. Masnada, D. Delia, F. Miccichè, C. Savio   +8 more
core  

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. [PDF]

, 1998
Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways.
Lindsay, Howard D., Merl F Hoekstra (16067846), Flaggs, Gail, Martinho, Rui G., Bentley, Nicola J., Howard D Lindsay (16062896), Hoekstra, Merl F., Antony M Carr (10744455), Rui G Martinho (16067837), Carr, Antony M., Anthony J DeMaggio (16067843), Nicola J Bentley (16067849), DeMaggio, Anthony J, Gail Flaggs (16067840)   +13 more
core  

Recruitment of Oct4 protein to UV-damaged chromatin in embryonic stem cells. [PDF]

, 2011
BACKGROUND: Oct4 is a specific marker of embryonic stem cell (ESC) pluripotency. However, little is known regarding how Oct4 responds to DNA damage. Here, we investigated whether Oct4 recognizes damaged chromatin in mouse ESCs stably expressing GFP-Oct4.
Kozubek, Stanislav, Foltankova, Veronika, Stanislav Kozubek, Gabriela Šustáčková, Lenka Stixová, Stixová Lenka, Soňa Legartová, Bartova, Eva, Veronika Foltánková, Kozubek Stanislav, Bártová Eva, Legartová Soňa, Foltánková Veronika, Stixova, Lenka, Legartova, Sona, Eva Bártová, Sustackova, Gabriela, Šustáčková Gabriela   +17 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source