Results 41 to 50 of about 310,740 (235)

Biotechnological tools boost the functional diversity of DNA-based data storage systems

Computational and Structural Biotechnology Journal
DNA-based data storage has emerged as a groundbreaking solution to the growing demand for efficient, high-density, and long-term data storage. It is attracting many researchers’ attention, who are implementing functions such as random access, searching ...
Xiaoyuan Xu, Wen Wang, Zhi Ping
doaj   +1 more source

Mobile and Self‐Sustained Data Storage in an Extremophile Genomic DNA

Advanced Science, 2023
DNA has been pursued as a novel biomaterial for digital data storage. While large‐scale data storage and random access have been achieved in DNA oligonucleotide pools, repeated data accessing requires constant data replenishment, and these ...
Fajia Sun, Yiming Dong, Ming Ni, Zhi Ping, Yuhui Sun, Qi Ouyang, Long Qian   +6 more
doaj   +1 more source

Biological constraint in digital data encoding: A DNA based approach for image representation

IJAIN (International Journal of Advances in Intelligent Informatics)
Digital data encoding is crucial for communication and data storage, but conventional techniques, such as ASCII and binary coding, have drawbacks in terms of processing speed and storage capacity.
Muhammad Rafi Muttaqin, Yeni Herdiyeni, Agus Buono, Karlisa Priandana, Iskandar Zulkarnaen Siregar, Wisnu Ananta Kusuma   +5 more
doaj   +1 more source

Towards Chinese text and DNA shift encoding scheme based on biomass plasmid storage

Frontiers in Bioinformatics, 2023
DNA, as the storage medium in organisms, can address the shortcomings of existing electromagnetic storage media, such as low information density, high maintenance power consumption, and short storage time.
Xu Yang, Langwen Lai, Xiaoli Qiang, Ming Deng, Yuhao Xie, Xiaolong Shi, Zheng Kou   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Cost‐Effective DNA Storage System with DNA Movable Type

Advanced Science
In the face of exponential data growth, DNA‐based storage offers a promising solution for preserving big data. However, most existing DNA storage methods, akin to traditional block printing, require costly chemical synthesis for each individual data file,
Chenyang Wang, Di Wei, Zheng Wei, Dongxin Yang, Jing Xing, Yunze Wang, Xiaotong Wang, Pei Wang, Guannan Ma, Xinru Zhang, Haolan Li, Chuan Tang, Pengfei Hou, Jie Wang, Renjun Gao, Guiqiu Xie, Cuidan Li, Yingjiao Ju, Peihan Wang, Liya Yue, Yongliang Zhao, Yongjie Sheng, Jingfa Xiao, Haitao Niu, Sihong Xu, Huaiyi Yang, Di Liu, Bo Duan, Dongbo Bu, Guangming Tan, Fei Chen   +30 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Hidden Addressing Encoding for DNA Storage

Frontiers in Bioengineering and Biotechnology, 2022
DNA is a natural storage medium with the advantages of high storage density and long service life compared with traditional media. DNA storage can meet the current storage requirements for massive data.
Penghao Wang, Ziniu Mu, Lijun Sun, Shuqing Si, Bin Wang   +4 more
doaj   +1 more source