Results 251 to 260 of about 96,036 (271)
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Demystifying DNA Demethylation
Science, 2011DNA modifying and repair enzymes make a new connection in the mechanism of DNA demethylation.
Christopher S. Nabel, Rahul M. Kohli
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Active DNA demethylation and DNA repair
Differentiation, 2009DNA methylation on cytosine is an epigenetic modification and is essential for gene regulation and genome stability in vertebrates. Traditionally DNA methylation was considered as the most stable of all heritable epigenetic marks. However, it has become clear that DNA methylation is reversible by enzymatic "active" DNA demethylation, with examples in ...
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Gadd45 in DNA Demethylation and DNA Repair
2022Growth arrest and DNA damage 45 (Gadd45) family genes, Gadd45A, Gadd45B, and GADD45 G are implicated as stress sensors that are rapidly induced upon genotoxic/physiological stress. They are involved in regulation of various cellular functions such as DNA repair, senescence, and cell cycle control.
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DNA demethylation and cancer: therapeutic implications
Cancer Letters, 2004The epigenome, which is comprised of chromatin and its associated proteins and the patterns of covalent modification of DNA by methylation, sets up and maintains gene expression programs. A hallmark of cancer is a paradoxical aberration of DNA methylation patterns, a global loss of DNA methylation, that coexists with regional hypermethylation of ...
Moshe, Szyf +2 more
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2016
The regulation of the genome relies on the overlying epigenome to instruct, define, and restrict the activities of cellular differentiation and growth integral to embryonic development, as well as defining the key activities of terminally differentiated cell types.
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The regulation of the genome relies on the overlying epigenome to instruct, define, and restrict the activities of cellular differentiation and growth integral to embryonic development, as well as defining the key activities of terminally differentiated cell types.
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Protein demethylation required for DNA methylation
Nature Genetics, 2009DNA methylation is an epigenetic mark directing stable, heritable gene silencing through development. A new study uncovers the importance of demethylation of the DNA methyltransferase-1 for maintenance of DNA methylation.
Hotz Hans-Rudolf, Peters Antoine H F M
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Science, 2011
Molecular Biology The methylation of DNA on cytosine (C) bases, most often at CpG sites, plays an important role in the epigenetic regulation of genomic imprinting, suppression of transposons and other parasitic DNA sequences, and X chromosome inactivation.
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Molecular Biology The methylation of DNA on cytosine (C) bases, most often at CpG sites, plays an important role in the epigenetic regulation of genomic imprinting, suppression of transposons and other parasitic DNA sequences, and X chromosome inactivation.
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DNA Demethylation: Where Genetics Meets Epigenetics
Current Pharmaceutical Design, 2014Epigenetic regulation is essential to the well-being of developing as well as developed cells by providing tissue-specific gene expression. DNA methylation on cytosine nucleotides is one of the core elements of epigenetic machinery, and stable DNA methylation patterns are maintained by properly regulated DNA methylation and DNA demethylation.
Xiaofei, Zhang +3 more
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Active DNA demethylation by Gadd45 and DNA repair
Trends in Cell Biology, 2012How DNA methylation patterns are established, maintained and remodeled is incompletely understood, however, it has become clear that DNA methylation is reversible and dynamic as a result of enzymatic DNA demethylation. Several different mechanisms that may account for demethylation have recently been put forward and all seem to involve DNA repair. Here,
Christof Niehrs, Andrea Schäfer
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DNA Methylation and Demethylation in Plant Immunity
Annual Review of Phytopathology, 2016Detection of plant and animal pathogens triggers a massive transcriptional reprogramming, which is directed by chromatin-based processes, and ultimately results in antimicrobial immunity. Although the implication of histone modifications in orchestrating biotic stress–induced transcriptional reprogramming has been well characterized, very little was ...
Deleris, A., Halter, T., Navarro, L.
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