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Improved CRISPR‐Cas12a‐assisted one‐pot DNA editing method enables seamless DNA editing
Biotechnology and Bioengineering, 2019AbstractAs the clustered regularly interspaced short palindromic repeats (CRISPR)–Cas12a (previously known as Cpf1) system cleaves double‐stranded DNA and produces a sticky end, it could serve as a useful tool for DNA assembly/editing. To broaden its application, a variety of engineered FnCas12a proteins are generated with expanded protospacer adjacent
Liping Wang +9 more
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C&EN Global Enterprise, 2020
One type of DNA has remained beyond the reach of precision genome-editing techniques like CRISPR.
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One type of DNA has remained beyond the reach of precision genome-editing techniques like CRISPR.
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Blood, 2015
Abstract RNA-guided Cas9 nucleases based on the prokaryotic CRISPR-Cas systems provide an unprecedented ease in being able to edit the genomes of diverse organisms. As a single unifying factor capable of co-localizing RNA, DNA, and protein, I believe tools and techniques based on Cas9 will grant exquisite control over cellular ...
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Abstract RNA-guided Cas9 nucleases based on the prokaryotic CRISPR-Cas systems provide an unprecedented ease in being able to edit the genomes of diverse organisms. As a single unifying factor capable of co-localizing RNA, DNA, and protein, I believe tools and techniques based on Cas9 will grant exquisite control over cellular ...
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RNA editing meets DNA shuffling
Nature, 2000The immune system can tailor its production of antibodies to the type of infection. Three sequential DNA-shuffling processes underlie this ability. The same protein is responsible for the last two of the processes, and oddly it is an RNA-editing rather than a DNA-recombining enzyme.
Ming Tian, Frederick W. Alt
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Future of human mitochondrial DNA editing technologies
Mitochondrial DNA Part A, 2018ATP and other metabolites, which are necessary for the development, maintenance, and functioning of bodily cells are all synthesized in the mitochondria. Multiple copies of the genome, present within the mitochondria, together with its maternal inheritance, determine the clinical manifestation and spreading of mutations in mitochondrial DNA (mtDNA ...
N. Verechshagina +6 more
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CRISPR Craft: DNA Editing the Reconstructive Ladder
Plastic & Reconstructive Surgery, 2018Summary: The clustered regularly interspaced short palindromic repeats (CRISPR) system of genome editing represents a major technological advance spanning all areas of genetics and downstream applications. CRISPR’s potential impact on treating human disease encompasses all clinical specialties, including areas important to the ...
Danny S, Roh +2 more
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Germline editing dominates DNA summit
Science, 2015Prospect of heritable changes sparks questions about safety, ethics, and rationale.
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Mitochondrial DNA editing with mitoARCUS
Nature Metabolism, 2023Denisa Hathazi, Rita Horvath
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Limited edition DNA print published
BMJ, 20032003 marks the 50th anniversary of the discovery of the DNA double helix by James Watson and Francis Crick in Cambridge in 1953. To …
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Recent advances in DNA-free editing and precise base editing in plants
Emerging Topics in Life Sciences, 2017Genome-editing technologies based on the CRISPR (clustered regularly interspaced short palindromic repeat) system have been widely used in plants to investigate gene function and improve crop traits. The recently developed DNA-free delivery methods and precise base-editing systems provide new opportunities for plant genome engineering.
Yi, Zhang, Caixia, Gao
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