Thermodynamic perspectives into DNA stability and information encoding in the human genome
Communications PhysicsThe perpetuation of species depends on two critical factors at the DNA level: the encoding of information essential for survival and adaptation, and the stability of DNA to preserve this information. Focusing on the latter, this study posits and confirms
Piero Fariselli, Amos Maritan
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A Multiple-Medical-Image Encryption Method Based on SHA-256 and DNA Encoding. [PDF]
Entropy (Basel), 2023 Wu J, Zhang J, Liu D, Wang X.
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
DNA-QLC: an efficient and reliable image encoding scheme for DNA storage
BMC GenomicsBackground DNA storage has the advantages of large capacity, long-term stability, and low power consumption relative to other storage mediums, making it a promising new storage medium for multimedia information such as images.
Yanfen Zheng +5 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Bacterial Expression of Gene‐Encoding DNA Origami Structures
Small StructuresPrevious studies have shown that DNA origamis assembled from gene‐encoding scaffolds can be taken up by mammalian cells and ultimately lead to the expression of the encoded genes.
Verena Dobretzberger +7 more
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The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus [PDF]
, 2011 Objectives The antistaphylococcal pyrrolobenzodiazepine dimer ELB-21 forms multiple adducts with duplex DNA through covalent interactions with appropriately spaced guanine residues; it is now known to form interstrand and intrastrand adducts with ...
Rahman, Khondaker; id_orcid +12 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
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A linear DNA encoding the SARS-CoV-2 receptor binding domain elicits potent immune response and neutralizing antibodies in domestic cats. [PDF]
Mol Ther Methods Clin Dev, 2023 Conforti A +16 more
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Construction and screening of plant genomic libraries [PDF]
, 1990 A library of pea (Pisum sativum L) genomic DNA in bacteriophage EMBL3 was screened for seed storage protein genes of the legumin and vicilin families. Three genomic clones were isolated.
Yaish, Sami Abdul-Rahman, Yaish, S.A
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