Results 251 to 260 of about 2,593,032 (311)

DNA Encoding of Natural Products

2022
DNA-encoded library (DEL) links the powers of genetics and chemicals via high-efficient enzymatic ligation of DNA barcodes and the "split and pool" combinatorial synthesis. Natural products (NPs) are evolutionary optimized compounds that have played a key role in the history of human drug discovery.
Hongtao, Xu, Peixiang, Ma
openaire   +2 more sources

Remarks on Relativisations and DNA Encodings

2003
Biomolecular computing requires the use of carefully crafted DNA words. We compare and integrate two known different theoretical approaches ([2,3]) to the encoding problem for DNA languages: one is based on a relativization of concepts related to comma free codes, the other is a generalization to any given mapping θ of the notion of words appearing as ...
FERRETTI, CLAUDIO, MAURI, GIANCARLO
openaire   +3 more sources

Codes, Involutions, and DNA Encodings

2002
DNA computing as a field started in 1994 when Leonard Adleman solved a hard computational problem entirely by manipulations of DNA molecules in a test tube [1]. The premise behind DNA computing is that DNA is capable of storing information, while various laboratory techniques that operate on and modify DNA strands (called bio-operations in the sequel ...
Lila Kari, Rob Kitto, Gabriel Thierrin
openaire   +1 more source

Digital Information Encoding on DNA

2003
Novel approaches to information encoding with DNA are explored using a new Watson-Crick structure for binary strings more appropriate to model DNA hybridization. First, a Gibbs energy analysis of codeword sets is obtained by using a template and extant error-correcting codes.
Max H. Garzon, Kiranchand V. Bobba, Bryan P. Hyde   +2 more
openaire   +1 more source

The Capacity of DNA for Information Encoding

2005
Information encoding and processing in DNA has proved to be an important problem for biomolecular computing, including the well studied codeword design problem. A lower bound is established for the capacity of DNA to encode information using a combinatorial model of DNA homology given by the so-called h-distance. This bound decreases exponentially with
Vinhthuy T. Phan, Max H. Garzon
openaire   +2 more sources

Mitochondrial DNA-encoded defects

Mitochondrial DNA (mtDNA)-related mitochondrial diseases are clinically heterogeneous, can occur at any age, and can manifest with a wide range of clinical symptoms. The complexity of mitochondrial disease necessitates clinical care and genetic and functional diagnostics at a dedicated center with the requisite expertise and intercollegial exchange.
Wagner, M., Wortmann, S.B.
openaire   +2 more sources

Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions

Ca-A Cancer Journal for Clinicians, 2021
Heather A Parsons, Atish Choudhury, Michael L Cheng   +2 more
exaly  

DNA scaffolds encoding messages

Nature Structural & Molecular Biology, 2023
openaire   +2 more sources

Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

Nature Reviews Molecular Cell Biology, 2022
Eva Petermann, Li Lan, Lee Zou
exaly  

The Progressing Clinical Utility of DNA Microarrays

Ca-A Cancer Journal for Clinicians, 2002
Jill A Macoska
exaly