Results 41 to 50 of about 2,593,032 (311)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Intra-epithelial vaccination with COPV L1 DNA by particle-mediated DNA delivery protects against mucosal challenge with infectious COPV in beagle dogs. [PDF]

, 2001
Protection against viral challenge with canine oral papillomavirus (COPV) was achieved by immunisation via particle-mediated DNA delivery (PMDD) of a plasmid encoding the COPV L1 gene to cutaneous and oral mucosal sites in beagle dogs.
Walcott, S., Nicholls, P.K., Thomsen, L., Stanley, M.A., Santos, E.B., Moore, R.A., Parry, N., Gough, G.   +7 more
core  

Musereduce : a generic framework for hierarchical music analysis

, 2023
In comparison to computational linguistics, with its abundance of natural-language datasets, corpora of music analyses are rather fewer and generally smaller. This is partly due to difficulties inherent to the encoding of music analyses, whose multimodal
Rammos, Yannis,, Rohrmeier, Martin,, Rammos, Yannis, Ericson, Petter,, Ericson, Petter, Rohrmeier, Martin   +5 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Encoding quantized fluorescence states with fractal DNA frameworks

Nature Communications, 2020
Though DNA framework-based scaffolds for biomolecular assembly are attractive for bioimaging applications, realizing super-multiplex fluorescent amplifiers remains a challenge.
Jiang Li, Jiangbing Dai, Shuoxing Jiang, Mo Xie, Tingting Zhai, Linjie Guo, Shuting Cao, Shu Xing, Zhibei Qu, Yan Zhao, Fei Wang, Yang Yang, Lei Liu, Xiaolei Zuo, Lihua Wang, Hao Yan, Chunhai Fan   +16 more
doaj   +1 more source

Comparative genomics of Shiga toxin encoding bacteriophages [PDF]

, 2012
Background Stx bacteriophages are responsible for driving the dissemination of Stx toxin genes (stx) across their bacterial host range. Lysogens carrying Stx phages can cause severe, lifethreatening disease and Stx toxin is an integral virulence factor.
Alan J McCarthy, Darby Alistair C, Alistair C Darby, Allison Heather E, Rooks David J, Rooks, David, Smith, Darren, Paul CM Fogg, Thomson, Nicholas, David J Rooks, Smith Darren L, McCarthy Alan J, McCarthy, Alan, Heather E Allison, Darren L Smith, Allison, Heather, Fogg Paul CM, Nick R Thomson, Fogg, Paul, Darby, Alistair, Thomson Nick R   +20 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis.

PLoS ONE, 2012
BackgroundRhomboids are ubiquitous proteins with unknown roles in mycobacteria. However, bioinformatics suggested putative roles in DNA replication pathways and metabolite transport.
David Patrick Kateete, Fred Ashaba Katabazi, Alfred Okeng, Moses Okee, Conrad Musinguzi, Benon Byamugisha Asiimwe, Samuel Kyobe, Jeniffer Asiimwe, W Henry Boom, Moses Lutaakome Joloba   +9 more
doaj   +1 more source

A Novel Hybrid Secure Method Based on DNA Encoding Encryption and Spiral Scrambling in Chaotic OFDM-PON

IEEE Photonics Journal, 2020
This paper proposes a novel hybrid secure method based on improved deoxyribonucleic acid (DNA) encoding encryption and spiral scrambling in chaotic OFDM-PON for enhancing the physical-layer security.
Yaoqiang Xiao, Yating Chen, Caixia Long, Jin Shi, Jie Ma, Jing He   +5 more
doaj   +1 more source