Results 271 to 280 of about 4,748,303 (367)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Portable DNA extraction integrated with LAMP-CRISPR/Cas12a technology for on-site detection of Salmonella Typhimurium. [PDF]

NPJ Sci Food
Zhang L, Zhang M, Liu X, Wei J, Yin C, Wang N, Fan B, Fu Y, Liu Y, Bu L, Su Z, Pang B, Li J, Song X.   +13 more
europepmc   +1 more source

Efficient recovery of environmental DNA for expression cloning by indirect extraction methods [PDF]

, 2003
Esther M. Gabor, Erik F. J. de Vries, Dick B. Janssen   +2 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Reducing DNA extraction costs through factorial design for the DNAdvance Kit. [PDF]

BMC Res Notes
Neal CJ, Zbinden ZD, Douglas ME, Douglas MR.   +3 more
europepmc   +1 more source

Detection of Herpes Simplex Virus DNA in Genital and Dermal Specimens by LightCycler PCR after Extraction using the IsoQuick, MagNA Pure, and BioRobot 9604 Methods

, 2001
Mark J. Espy, Paul N. Rys, Arlo D. Wold, James R. Uhl, Lynne M. Sloan, G. Douglas Jenkins, Duane M. Ilstrup, F. R. Cockerill, Robin Patel, Jon E. Rosenblatt, Thomas F. Smith   +10 more
openalex   +1 more source

Evaluation of five DNA extraction methods for purification of DNA from atherosclerotic tissue and estimation of prevalence of Chlamydia pneumoniae in tissue from a Danish population undergoing vascular repair. [PDF]

, 2003
Tina Mygind, Lars Østergaard, Svend Birkelund, Jes S. Lindholt, Gunna Christiansen   +4 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Making the best of a bad sample: Comparison of DNA extraction and quantification methods using sub-optimally stored Ixodes ricinus ticks. [PDF]

PLoS One
Cotes-Perdomo AP, Méndez-Gutierrez K, Alfsnes K, Andreassen ÅK, Jenkins A.   +4 more
europepmc   +1 more source

Incorporation of Sodium Sulfite into Extraction Protocol Minimizes Degradation of Acacia DNA

, 2001
Margaret Byrne, Bronwyn MacDonald, Michael G. Francki   +2 more
openalex   +1 more source