Results 91 to 100 of about 94,582 (271)
Advanced Science, EarlyView.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Peptide mass fingerprinting using field-programmable gate arrays [PDF]
, 2009 The reconfigurable computing paradigm, which exploits the flexibility and versatility of field-programmable gate arrays (FPGAs), has emerged as a powerful solution for speeding up time-critical algorithms.
Beynon, R.J., Bogdan, I.A., Coca, D.
core +1 more source
Advanced Science, EarlyView.It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou +8 more
wiley +1 more source
, 2006 The biophysical differences between different kinds of DNA data banks are described. The different ethical implications of DNA fingerprint data banks, data banks of known gene sequences, and data banks of total genomic sequences are considered.
Stewart, J.A.
core
AFLPs: genetic markers for paternity studies in newts (Triturus vulgaris) [PDF]
, 2006 DNA-based genetic markers can reveal paternity whenever the direct assignment of fathers to offspring is precluded by multiple matings and internal fertilisation.
Jehle, R, Sztatecsny, M, Whitlock, A
core +2 more sources
Engineering Microbial Particles for Next‐Generation Biomedical Platforms
Advanced Science, EarlyView.Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li +7 more
wiley +1 more source
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7
Nature Communications, 2016 Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is ...
Swapnil Rohidas Shinde +1 more
doaj +1 more source
Genetic diversity, population structure, and DNA fingerprinting of Ailanthus altissima var. erythrocarpa based on EST-SSR markers. [PDF]
Sci Rep, 2023 Zhang M +7 more
europepmc +1 more source
Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing
Advanced Science, EarlyView.Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu +7 more
wiley +1 more source
Aspartyl proteases target host actin nucleator complex protein to limit epithelial innate immunity
EMBO ReportsEpithelial-immune cell communication is pivotal to control microbial infections. We show that glycosylphosphatidylinositol-linked aspartyl proteases (Yapsins) of the human opportunistic pathogenic yeast Candida glabrata (Cg) thwart epithelial cell (EC ...
Sandip Patra, Rupinder Kaur
doaj +1 more source