Results 81 to 90 of about 94,582 (271)

Mapping of a major QTL for salt tolerance of mature field-grown maize plants based on SNP markers

BMC Plant Biology, 2017
Background Salt stress significantly restricts plant growth and production. Maize is an important food and economic crop but is also a salt sensitive crop.
Meijie Luo, Yanxin Zhao, Ruyang Zhang, Jinfeng Xing, Minxiao Duan, Jingna Li, Naishun Wang, Wenguang Wang, Shasha Zhang, Zhihui Chen, Huasheng Zhang, Zi Shi, Wei Song, Jiuran Zhao   +13 more
doaj   +1 more source

FASLG Derived from Fibroblasts in Hydroxyapatite‐Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure

Advanced Science, EarlyView.
Randall's plaques (RP) serve as the nidus for calcium oxalate (CaOx) kidney stones. The current study reveals that hydroxyapatite (HAP) crystals activate the THY1–GSK3α/β–β‐catenin axis in renal interstitial fibroblasts (hRIFs), inducing FASLG secretion.
Minghui Liu, Maolan Wu, Meng Gao, Yongchao Li, Miao Yuan, Zhangcheng Liao, Zhi Liu, Yizhou Wang, Yu Cui, Jinbo Chen, Cheng He, Zhiyong Chen, Feng Zeng, Hequn Chen, Zewu Zhu   +14 more
wiley   +1 more source

Exploring differentially expressed genes associated with fertility instability of S-type cytoplasmic male-sterility in maize by RNA-seq

Journal of Integrative Agriculture, 2017
: The germplasm resources for the S-type male sterility is rich in maize and it is resistant to Bipolaris maydis race T and CI, but the commercial application of S-type cytoplasmic male sterility (CMS-S) in maize hybrid industry is greatly compromised ...
Ai-guo SU, Wei SONG, Zi SHI, Yan-xin ZHAO, Jin-feng XING, Ru-yang ZHANG, Chun-hui LI, Meijie LUO, Ji-dong WANG, Jiu-ran ZHAO   +9 more
doaj   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Protocol for analyzing chromatin dynamics in macrophage-internalized Candida glabrata cells using micrococcal nuclease digestion

STAR Protocols
Summary: Chromatin dynamics plays an important role in medical mycology. Here, we present a protocol to identify nucleosome occupancy and positioning in the fungal pathogen Candida glabrata (Nakaseomyces glabratus).
Kundan Kumar, Aditi Pareek, Rupinder Kaur   +2 more
doaj   +1 more source

Genetic diversity of X-STR markers in Jat Sikh population of Punjab, India and its comparison with other 39 global populations

Annals of Human Biology, 2020
Background The Jat Sikh population is the largest endogamous group of Punjab, a state in north-west India, and has not yet been explored for genetic polymorphism based on X-STR genetic markers.
Sonia Kakkar, Pankaj Shrivastava, Vivek Sahajpal, Arun Sharma, Nisha Devi, S. P. Mandal, R. K. Kumawat   +6 more
doaj   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Maryland v. King: The Fourth Amendment Spirals Down the Double Helix [PDF]

, 2013
This commentary previews an upcoming Supreme Court case, Maryland v. King, in which the Court may decide whether requiring an arrestee to submit to a buccal swab for identification purposes violates the arrestee\u27s privacy interests under the Fourth ...
Witanachchi, Sitara V.
core   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Induction of plant resistance to bean common mosaic virus (BCMV) via multiple applications of nanoparticle-conjugated dsRNA

BMC Plant Biology
Bean common mosaic virus (BCMV) is regarded as the most destructive to common beans, capable of causing yield losses of up to 100%. A non-transgenic approach involving the topical application of dsRNA to induce RNA interference is increasingly being ...
Nulevino Iralu, Sumiah Wani, Shahjahan Rashid, Farhana Wani, Dasari Meghanath, Gowhar Ali, Aflaq Hamid   +6 more
doaj   +1 more source