Results 281 to 290 of about 20,880 (290)
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1981
Publisher Summary DNA glycosylases are ubiquitous in nature and essentially hydrolyze nucleoside base–glycosidic bonds. The reaction results in the production of an apurinic/apyrimidinic (AP) site in DNA and a free nucleoside base. These enzymes also participate in DNA repair processes by catalyzing the removal of unconventional or damaged bases from
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Publisher Summary DNA glycosylases are ubiquitous in nature and essentially hydrolyze nucleoside base–glycosidic bonds. The reaction results in the production of an apurinic/apyrimidinic (AP) site in DNA and a free nucleoside base. These enzymes also participate in DNA repair processes by catalyzing the removal of unconventional or damaged bases from
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Urea-DNA glycosylase in mammalian cells
Biochemistry, 1983Urea-DNA glycosylase, an enzyme presumed to be active in the repair of DNA damage caused by oxidizing agents, has been identified previously in Escherichia coli. This enzyme has now been shown to be present in cell extracts of calf thymus and human fibroblasts.
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DNA GLYCOSYLASES OF ESCHERICHIA COLI
1978ABSTRACT E. coli contain several different enzymes which catalyze the hydrolytic release of unusual or damaged bases from DNA, with the consequent formation of apurinic or apyrimidinic sites. These enzymes are of relatively low molecular weight and do not require cofactors. Each enzyme is highly specific for a particular kind of lesion.
Tomas Lindahl, S. Riazuddin, P. Karran
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Prophylaxis of oxidative DNA damage by formamidopyrimidine‐DNA glycosylase
International Journal of Cancer, 2006AbstractLying at the gas‐exchange interface, lung epithelia may be at risk of oxidation‐induced mutagenesis. Further, inflammation processes possibly consequent on smoking liberate reactive oxygen species that multiply the carcinogenic effects of tobacco.
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The Use of DNA Glycosylases to Detect DNA Damage
1996DNA glycosylases, first reported by Lindahl (1974), catalyze the scission of the glycosidic bond releasing damaged or mispaired bases as the first step of the base excision repair pathway (Fig. 12.1) (Dianov and Lindahl, 1994). Removal of damaged bases by a DNA glycosylase is generally associated with a specific type of damage (e.g., uracil-DNA ...
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The influence of DNA glycosylases on spontaneous mutation
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998Brian J. Glassner +2 more
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