Results 41 to 50 of about 20,880 (290)

Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy [PDF]

, 2013
Uracil in DNA is an important cause of mutagenesis. SMUG1 is a uracil DNA glycosylase that removes uracil through base excision repair. SMUG1 also processes radiation induced oxidative base damage as well as 5-fluorouracil incorporated into DNA during
Abdel-Fatah, TMA, Agarwal, D, Albarakati, N, Ball, G, Bowell, L, Chan, S, Ellis, IO, Hawkes, C, Madhusudan, S, Moseley, P   +9 more
core   +1 more source

Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation

Communications Biology, 2023
The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome.
Angela Cabral, Julia Elise Cabral, Angelina Wang, Yiyang Zhang, Hailin Liang, Donya Nikbakht, Leslie Corona, Hal M. Hoffman, Reginald McNulty   +8 more
doaj   +1 more source

The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli

Cells, 2022
Escherichia coli apurinic/apyrimidinic (AP) endonuclease Nfo is one of the key participants in DNA repair. The principal biological role of this enzyme is the recognition and hydrolysis of AP sites, which arise in DNA either as a result of the ...
Svetlana I. Senchurova, Aleksandra A. Kuznetsova, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov   +5 more
doaj   +1 more source

Molecular Mechanisms Associated with Clustered Lesion-Induced Impairment of 8-oxoG Recognition by the Human Glycosylase OGG1

Molecules, 2021
The 8-oxo-7,8-dihydroguanine, referred to as 8-oxoG, is a highly mutagenic DNA lesion that can provoke the appearance of mismatches if it escapes the DNA Damage Response.
Tao Jiang, Antonio Monari, Elise Dumont, Emmanuelle Bignon   +3 more
doaj   +1 more source

Structural insight into repair of alkylated DNA by a new superfamily of DNA glycosylases comprising HEAT-like repeats [PDF]

, 2007
3-methyladenine DNA glycosylases initiate repair of cytotoxic and promutagenic alkylated bases in DNA. We demonstrate by comparative modelling that Bacillus cereus AlkD belongs to a new, fifth, structural superfamily of DNA glycosylases with an alpha ...
Alseth, Altschul, Andrade, Andrade, Andreeva, Baker, Barnes, Berman, Bjelland, Bjelland, Bjørn Dalhus, Brunger, Bryson, Cao, Clamp, Clarke, Cuff, Delano, Dodson, Dolinsky, Eichman, Fromme, Hollis, Hooft, Huber, Huffman, Ina Høydal Helle, Ingrun Alseth, Jon K. Laerdahl, Jones, Karplus, Kelley, Krokan, Labahn, Landau, Lau, Lau, Li, Magnar Bjørås, Mayrose, McGuffin, O'Brien, O'Brien, O'Rourke, Obradovic, Park, Paul H. Backe, Poirot, Pollastri, Rost, Rost, Schwede, Seeberg, Stivers, Sæbø, Torbjørn Rognes, Ward, Wood, Yamagata   +58 more
core   +2 more sources

Structure of a DNA Glycosylase Searching for Lesions [PDF]

Science, 2006
DNA glycosylases must interrogate millions of base pairs of undamaged DNA in order to locate and then excise one damaged nucleobase. The nature of this search process remains poorly understood. Here we report the use of disulfide cross-linking (DXL) technology to obtain structures of a bacterial DNA glycosylase, MutM, interrogating undamaged DNA. These
Webster L. Santos, Anirban Banerjee, Gregory L. Verdine   +2 more
openaire   +3 more sources

Thymine DNA Glycosylase Is a CRL4Cdt2 Substrate [PDF]

Journal of Biological Chemistry, 2014
The E3 ubiquitin ligase CRL4(Cdt2) targets proteins for destruction in S phase and after DNA damage by coupling ubiquitylation to DNA-bound proliferating cell nuclear antigen (PCNA). Coupling to PCNA involves a PCNA-interacting peptide (PIP) degron motif in the substrate that recruits CRL4(Cdt2) while binding to PCNA.
Tatsuro S. Takahashi, Benjamin Morris, Johannes C. Walter, Johannes C. Walter, Tamara J. Slenn, Courtney G. Havens, Robert Freeman   +6 more
openaire   +3 more sources

Redmond Red as a Redox Probe for the DNA-Mediated Detection of Abasic Sites [PDF]

, 2008
Redmond Red, a fluoropore containing a redox-active phenoxazine core, has been explored as a new electrochemical probe for the detection of abasic sites in double-stranded DNA.
Barton, Jacqueline K., Buzzeo, Marisa C.
core   +2 more sources

Uracil-DNA glycosylase. Purification and properties of uracil-DNA glycosylase from Micrococcus luteus. [PDF]

Journal of Biological Chemistry, 1982
A uracil-DNA-glycosylase from Micrococcus luteus has been purified more than 3,000-fold. The enzyme preparation appears homogeneous, according to the results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. It is devoid of nonspecific endonucleases, specific endonucleases for apurinic and apyrimidinic sites, 3-methyladenine or 7 ...
J P Leblanc, Jacques Laval, B Martin, J Cadet   +3 more
openaire   +2 more sources

The Base Excision Repair Pathway in the Nematode Caenorhabditis elegans

Frontiers in Cell and Developmental Biology, 2020
Exogenous and endogenous damage to the DNA is inevitable. Several DNA repair pathways including base excision, nucleotide excision, mismatch, homologous and non-homologous recombinations are conserved across all organisms to faithfully maintain the ...
Noha Elsakrmy, Qiu-Mei Zhang-Akiyama, Dindial Ramotar   +2 more
doaj   +1 more source