Results 111 to 120 of about 1,489,376 (287)
DNA helicases: expression, functions and clinical implications
, 2015 Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules.
Fumiaki Uchiumi +2 more
core +1 more source
The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius [PDF]
, 2008 Background: The ubiquitous Rad50 and Mre11 proteins play a key role in many processes involved in the maintenance of genome integrity in Bacteria and Eucarya, but their function in the Archaea is presently unknown.
Patrick Forterre +10 more
core +1 more source
RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging
Biological Reviews, EarlyView.ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad +5 more
wiley +1 more source
The conformational changes coupling ATP hydrolysis and translocation in a bacterial DnaB helicase
Nature Communications, 2019 DnaB helicases are motor proteins that couple ATP-hydrolysis to the movement of the protein along single-stranded DNA leading to a separation of double-stranded DNA at the replication fork.
Thomas Wiegand +6 more
doaj +1 more source
eLife, 2017 Replicative helicases are ring-shaped hexamers that encircle DNA for duplex unwinding. The currently accepted view of hexameric helicase function is by steric exclusion, where the helicase encircles one DNA strand and excludes the other, acting as a ...
Lance Langston, Mike O’Donnell
doaj +1 more source
A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin
Chemistry – A European Journal, EarlyView.The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You +13 more
wiley +1 more source
DNA translocation mechanism of an XPD family helicase
eLife, 2018 The XPD family of helicases, that includes human disease-related FANCJ, DDX11 and RTEL1, are Superfamily two helicases that contain an iron-sulphur cluster domain, translocate on ssDNA in a 5’−3’ direction and play important roles in genome stability ...
Kaiying Cheng, Dale B Wigley
doaj +1 more source
Characterization of the telomerase modulating activities of yeast DNA helicases. [PDF]
Methods Enzymol, 2021 Nickens DG, Bochman ML.
europepmc +1 more source
RECQL: a DNA helicase in breast cancer
Oncotarget, 2015 We recently reported that mutations in the RECQL gene are associated with an increased risk of breast cancer [1]. We identified recurrent RECQL mutations in two founder populations in Poland and Quebec, Canada, and we found that these mutations increase the risk of breast cancer by 5-fold among unselected cases from Poland and by 16-fold among higher ...
Mohammad R, Akbari, Cezary, Cybulski
openaire +2 more sources
Developmental Dynamics, EarlyView.Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard +3 more
wiley +1 more source