Results 121 to 130 of about 47,217 (278)

Characterization of the telomerase modulating activities of yeast DNA helicases. [PDF]

Methods Enzymol, 2021
Nickens DG, Bochman ML.
europepmc   +1 more source

A DNA helicase from human cells

Nucleic Acids Research, 1990
We have initiated the characterization of the DNA helicases from HeLa cells, and we have observed at least 4 molecular species as judged by their different fractionation properties. One of these only, DNA helicase I, has been purified to homogeneity and characterized.
N, Tuteja, R, Tuteja, K, Rahman, L Y, Kang, A, Falaschi   +4 more
openaire   +3 more sources

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage

Cell Reports, 2018
Summary: R-loops comprise an RNA/DNA hybrid and displaced single-stranded DNA. They play important biological roles and are implicated in pathology. Even so, proteins recognizing these structures are largely undefined.
Agnese Cristini, Matthias Groh, Maiken S. Kristiansen, Natalia Gromak   +3 more
doaj   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Helicase promotes replication re-initiation from an RNA transcript

Nature Communications, 2018
During DNA replication, replicative helicases play an essential role for DNA unwinding to occur. Here the authors find that bacteriophage T7 helicase is also involved in replication re-initiation by interacting with a non-replicating DNAP and increasing ...
Bo Sun, Anupam Singh, Shemaila Sultana, James T. Inman, Smita S. Patel, Michelle D. Wang   +5 more
doaj   +1 more source

RETRACTED: The structure of SV40 large T hexameric helicase in complex with AT-rich origin DNA

eLife, 2016
DNA replication is a fundamental biological process. The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin.
Dahai Gai, Damian Wang, Shu-Xing Li, Xiaojiang S Chen   +3 more
doaj   +1 more source

Insight into the biochemical mechanism of DNA helicases provided by bulk-phase and single-molecule assays. [PDF]

Methods, 2022
Bianco PR.
europepmc   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Special Issue: DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance. [PDF]

Genes (Basel), 2021
Brosh RM.
europepmc   +1 more source