Results 241 to 250 of about 635,921 (300)

Integrated Single‐Cell and Spatial Transcriptomics Reveal Cell‐Type‐Specific Immune Regulatory Networks in Maize Responding to Southern Corn Rust

Advanced Science, EarlyView.
By integrating single‐nuclei and spatial transcriptomics, this study presents a stereoscopic landscape of maize leaf to Puccinia polysora infection. Epidermal and mesophyll cells initiate primary defenses via RLPs/RLKs and jasmonic acid signaling. Cell‐cell communication analyses further reveal the underlying the dynamics of the underlying immune ...
Qiongqiong Wang, Xinyan Sun, Yingchao Sun, Zeqiang Cheng, Zixiang Cheng, Shengbo Han, Ying Feng, Wenbo Yang, Huimin Li, Meichen Zhu, Xiaoling Wu, Jinghua Zhang, Jihua Tang, Honglian Li, Yanyong Cao, Canxing Duan, Yan Shi   +16 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

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Automated DNA Hybridization

Analytical Biochemistry, 1994
We have developed a system which fully automates the process of membrane-immobilized DNA hybridization. The system consists of three major parts: (i) a membrane-processing cassette which is thermo-controlled and which can hold multiple membranes simultaneously; (ii) a fluidic system which consists of seven independent input channels, a collecting waste
R P, Alderton, J, Kitau, S, Beck
openaire   +2 more sources

DNA—RNA hybridization

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975
Interest in nucleic acid hybridization stems mainly from its great power as a tool in biological research. It is used in several quite distinct ways. Because of the high degree of specificity that they show, hybridization techniques can be used to measure the amount of one specific sequence within a very heterogeneous mixture of sequences.
J O, Bishop, J S, Beckmann, M S, Campo, N D, Hastie, M, Izquierdo, S, Perlman   +5 more
openaire   +2 more sources

Complementary DNA-DNA hybridization in Drosophila

Journal of Molecular Evolution, 1992
We have performed DNA-DNA hybridization experiments among several species of Drosophila using the evolutionarily conserved portion of the genome representing sequences coding for amino acids of proteins. This was done by using as tracer, radioactively labeled complementary DNA that was reverse transcribed from adult mRNA.
A, Caccone, J M, Gleason, J R, Powell
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Potentiometric monitoring DNA hybridization

Biosensors and Bioelectronics, 2009
The usual procedure to monitor the ion exchange of small ions utilizes a potentiometer with a selective membrane as part of the working electrode. As the next step, we have applied polyaniline electrodes to the monitoring the activity macromolecular ions during DNA hybridization.
Y, Zhou, B, Yu, A, Guiseppi-Elie, V, Sergeyev, K, Levon   +4 more
openaire   +2 more sources

Cellulose/DNA Hybrid Nanomaterials

Biomacromolecules, 2009
Cellulose nanocrystals (CNXLs) have drawn attention from researchers for their remarkable reinforcing abilities and excellent mechanical properties. CNXLs typically have high aspect ratios of around 20-50 (length/width), low density of around 1.6 g/cc, high stiffness (135 to 155 GPa), and strength (estimated at 7500 MPa).
Anand P, Mangalam, John, Simonsen, Albert S, Benight   +2 more
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DNA-SWNT hybrid hydrogel

Chemical Communications, 2011
In this communication, we report the preparation of DNA-SWNT hybrid hydrogel which is pH responsive and strength tunable.
Enjun, Cheng, Yulin, Li, Zhongqiang, Yang, Zhaoxiang, Deng, Dongsheng, Liu   +4 more
openaire   +2 more sources

DNA-RNA HYBRIDIZATION

Acta Endocrinologica, 1972
ABSTRACT The kinetics of ideal DNA-RNA hybridization reactions are described, and some deviations from ideal behaviour are noted. The characteristics of RNA excess and DNA excess reactions are described, and different approaches to experimental situations are discussed.
openaire   +2 more sources