Results 121 to 130 of about 817,746 (315)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Isolation of DNA from Neurospora

, 1964
Isolation of DNA from ...
A. G. DeBusk, Brandt, E. E., E. E. Brandt, DeBusk, A. G.   +3 more
core   +1 more source

Analysis of microbial composition and sharing in low-biomass human milk samples: a comparison of DNA isolation and sequencing techniques [PDF]

ISME Commun, 2023
Spreckels JE, Fernández-Pato A, Kruk M, Kurilshikov A, Garmaeva S, Sinha T, Ghosh H, Harmsen H, Fu J, Gacesa R, Zhernakova A.   +10 more
europepmc   +2 more sources

Benchmarking DNA isolation methods for marine metagenomics. [PDF]

Sci Rep, 2023
Demkina A, Slonova D, Mamontov V, Konovalova O, Yurikova D, Rogozhin V, Belova V, Korostin D, Sutormin D, Severinov K, Isaev A.   +10 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Length determination of the terminal redundant regions in the DNA of phage T7

, 1980
Dreiseikelmann B, Steger U, Wackernagel W. Length determination of the terminal redundant regions in the DNA of phage T7. Molecular and General Genetics.
Steger, Ursula, Dreiseikelmann, Brigitte, Wackernagel, Wilfried   +2 more
core   +1 more source

Comparison of Two Different DNA Isolation Methods (Quick & Dirty vs. Commercial Kit) in Small Insects

Turkish Journal of Agriculture: Food Science and Technology
The COI gene region is the most commonly employed method for species identification in insects, as in all animals. The importance of DNA isolation methods is increasing, and they are of great importance for identifying insects. Unlike other large animals,
Ferhat Kiremit, Fulya Kaya Apak, Hayrettin İlker Özdemir, Gül Ayar   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Recovering short DNA fragments from minerals and marine sediments: A comparative study evaluating lysis and isolation approaches

Environmental DNA
Marine sediments as excellent climate archives, contain among other biomolecules substantial amounts of extracellular DNA. Through mineral binding, some of the DNA remains protected from degradation which aids its preservation.
Darjan Gande, Christiane Hassenrück, Marina Žure, Tim Richter‐Heitmann, Eske Willerslev, Michael W. Friedrich   +5 more
doaj   +1 more source