Results 161 to 170 of about 2,162,763 (370)
Cell transformation in tumor-development: a result of accumulation of Misrepairs of DNA through many generations of cells [PDF]
arXiv, 2015 Development of a tumor is known to be a result of accumulation of DNA changes in somatic cells. However, the processes of how DNA changes are produced and how they accumulate in somatic cells are not clear. DNA changes include two types: point DNA mutations and chromosome changes.
arxiv
Smc5/6: a link between DNA repair and unidirectional replication? [PDF]
, 2008 Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada +46 more
core +1 more source
Kinetic Characterization of Single Strand Break Ligation in Duplex DNA by T4 DNA Ligase
Journal of Biological Chemistry, 2011 Background: T4 DNA ligase catalyzes the formation of phosphodiester bonds in dsDNA. Results: Single turnover rates of all chemical reaction steps exceed steady state turnover rates by 10-fold.
G. Lohman, Lixin Chen, T. C. Evans
semanticscholar +1 more source
The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells
Advanced Science, EarlyView.RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp +5 more
wiley +1 more source
Case Report: Hypomorphic Ligase 4 deficiency – a paradigm of immunodysregulation
Frontiers in ImmunologyDNA Ligase 4 is critical to nonhomologous end joining, necessary for V(D)J recombination in T and B cell development. Ligase 4 deficiency is a rare autosomal recessive disorder caused by hypomorphic mutations in the DNA Ligase 4 gene, that can lead to a ...
Catarina Andrade +8 more
doaj +1 more source
Biology Direct, 2009 Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV ...
Koonin Eugene V, Yutin Natalya
doaj +1 more source
Advanced Science, EarlyView.This study verifies that circRNA‐mTOR exhibits high expression levels in HCC and has a strong correlation with patient prognosis. Mechanistically, circRNA‐mTOR achieves this effect by facilitating the nuclear translocation of RNA‐binding protein (RBP) PSIP1 through specific binding.
Yongchang Tang +12 more
wiley +1 more source
SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease
Advanced Science, EarlyView.SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi +11 more
wiley +1 more source
PLoS Pathogens, 2015 Uncontrolled immune responses to intracellular DNA have been shown to induce autoimmune diseases. Homeostasis regulation of immune responses to cytosolic DNA is critical for limiting the risk of autoimmunity and survival of the host. Here, we report that
Yanming Wang +9 more
doaj +1 more source
The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F
mSphere, 2016 The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny.
Frédéric Dallaire +5 more
doaj +1 more source