Advanced Science, EarlyView.The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang +8 more
wiley +1 more source
DNA ligase IV mutations confer shorter lifespan and increased sensitivity to nutrient stress in Drosophila melanogaster. [PDF]
J Appl Genet, 2022 Joshi R +3 more
europepmc +1 more source
DNA Ligase IV and XRCC4 Form a Stable Mixed Tetramer That Functions Synergistically with Other Repair Factors in a Cell-free End-joining System [PDF]
, 2000 Kyung Jong Lee +3 more
openalex +1 more source
Advanced Science, EarlyView.An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou +30 more
wiley +1 more source
Head inactivation of DNA ligase prior to electroporation increases transformation efficiency
, 1991 S. Ymer
openalex +2 more sources
Is the detection of Mycobacterium tuberculosis DNA by ligase chain reaction worth the cost: experiences from an inner London teaching hospital [PDF]
, 2000 Nandini Shetty
openalex +1 more source
SP3 and DEP1 Orchestrate Panicle Architecture by Jointly Regulating APO2 Expression in Rice
Advanced Science, EarlyView.The transcription factor SP3 enhances inflorescence meristem activity and interacts with the cysteine‐rich domain of DEP1. This interaction alters DEP1's subcellular localization between the plasma membrane and nucleus, and suppresses SP3‐mediated transcriptional activation of APO2.
Yuexin Liu +11 more
wiley +1 more source
Berberine Sensitises Breast Cancer Cells to Radiation via the Attenuation of DNA Ligase III. [PDF]
J Cell Mol MedSun Y +8 more
europepmc +1 more source
Rsp5, a Ubiquitin-Protein Ligase, Is Involved in Degradation of the Single-Stranded-DNA Binding Protein Rfa1 in Saccharomyces cerevisiae [PDF]
, 2000 Naz Erdeniz, Rodney Rothstein
openalex +1 more source