Results 241 to 250 of about 354,326 (330)

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Molecular docking analysis of DNA ligase from Staphylococcus aureus with identical polysaccharides. [PDF]

Bioinformation, 2020
Roy A, Sleeba AV, Joy R, Rajagopal P.
europepmc   +1 more source

DNA Ligase 1 [PDF]

, 2020
openaire   +1 more source

Cellular DNA Ligase I Is Recruited to Cytoplasmic Vaccinia Virus Factories and Masks the Role of the Vaccinia Ligase in Viral DNA Replication [PDF]

, 2009
Nir Paran, Frank S. De Silva, Tatiana G. Senkevich, Bernard Moss   +3 more
openalex   +1 more source

EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets

Advanced Science, EarlyView.
Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang, Fujun Hou, Xunuo Jin, Yuhang Xiang, Dongli Pan   +4 more
wiley   +1 more source

A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation. [PDF]

BMC Microbiol
Pan J, Singh A, Hanning K, Hicks J, Williamson A.   +4 more
europepmc   +1 more source

DNA Ligase III Is Degraded by Calpain during Cell Death Induced by DNA-damaging Agents

, 2002
Laura Bordone, Colin Campbell
openalex   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining. [PDF]

Nat Commun
Stinson BM, Carney SM, Walter JC, Loparo JJ.   +3 more
europepmc   +1 more source

An Alternative Splicing Event Which Occurs in Mouse Pachytene Spermatocytes Generates a Form of DNA Ligase III with Distinct Biochemical Properties That May Function in Meiotic Recombination

, 1997
Zachary B. Mackey, William Ramos, David S. Levin, Christi A. Walter, John R. McCarrey, Alan E. Tomkinson   +5 more
openalex   +2 more sources