Results 251 to 260 of about 208,982 (285)

Advances in miRNA research: Unraveling the complexities of gene regulation

Animal Models and Experimental Medicine, EarlyView.
Overview of miRNA‐mediated regulation in key biological processes. This illustration offers a comprehensive view of the diverse functions that microRNAs perform in governing various biological processes, highlighting their profound significance within the complex web of gene expression and cellular function.
Jiawei Zheng, Guoqing Zhang, Linzhu Ren
wiley   +1 more source

Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. [PDF]

DNA Repair (Amst), 2017
Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE.   +6 more
europepmc   +1 more source

Cloning and Functional Characterization of an NAD ⁺ -Dependent DNA Ligase from Staphylococcus aureus

, 2001
Frank S. Kaczmarek, Richard P. Zaniewski, Thomas D. Gootz, Dennis E. Danley, Mahmoud N. Mansour, Matt Griffor, Ajith V. Kamath, Melissa Cronan, John Mueller, Dongxu Sun, Patrick K. Martin, Bret M. Benton, Laura McDowell, Donald Biek, Molly B. Schmid   +14 more
openalex   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

High‐Throughput Engineering and Modification of Non‐Ribosomal Peptide Synthetases Based on Golden Gate Assembly

Angewandte Chemie, EarlyView.
A Golden Gate Assembly (GGA)‐based method was developed for the efficient assembly of natural and engineered non‐ribosomal peptide synthetases (NRPS). This method has enabled the creation of NRPS libraries to generate novel peptides in high‐throughput as well as the targeted derivatisation of natural products (NPs).
Adrian Podolski, Timon A. Lindeboom, Leonard Präve, Maryam Dehghan, Hannah A. Minas, Janik Kranz, Daniel Schindler, Helge B. Bode   +7 more
wiley   +2 more sources

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
Yaqiang Hu et al. engineered a pathogenic Sec16a mutant mouse model using CRISPR/Cas9 technology. They observed that the Sec16a mutant mice displayed diminished learning and memory capabilities, along with a limb‐clasping phenotype upon tail suspension.
Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Yuting Guan, Liangcai Gao, Dali Li   +6 more
wiley   +1 more source

Biomedical Applications of Nanozymes: An Enzymology Perspective

Angewandte Chemie, EarlyView.
With a lens of enzymology, this review compares nanozymes with enzymes using the Michaelis‐Menten model and differences in KM and kcat along with catalysis in complex biological environment. The implications of these differences in biomedical applications of nanozymes are then described with a statistical analysis of the trend of therapeutic use of ...
Vasily G. Panferov, Xiaohan Zhang, Ka‐Ying Wong, Jung Heon Lee, Juewen Liu   +4 more
wiley   +2 more sources

Nucleic Acid‐Based Molecular Machines for Biological Applications

Advanced NanoBiomed Research, EarlyView.
Molecular machines are devices assembled from molecules with specific functions. In this review, the development of DNA nanostructures, which are then assembled into molecular machines, is summarized. Their classification and biological applications, such as biosensing, targeted therapy, and molecular circuits are introduced.
Yirong Guo, Xiaolei Zuo, Fangfei Yin
wiley   +1 more source

Three‐Segment Protein Labeling Using a Highly Efficient and Cysteine‐Less Split Intein Identified with Computational Prediction of Aggregation Properties

Angewandte Chemie, EarlyView.
Tandem protein trans‐splicing (PTS) assembles a protein from three segments. Expanding this technology to individually treat cysteines in each segment, for example, for chemical labeling using thiol bioconjugation, the authors identify a second, highly efficient cysteine‐less split intein.
Christoph Humberg, Jonas Kröger, Shmuel Pietrokovski, Henning D. Mootz   +3 more
wiley   +2 more sources

DNA LIGASE IV SYNDROME: A RARE CAUSE OF GROWTH FAILURE & HYPOGONADISM. [PDF]

AACE Clin Case Rep, 2019
Iyengar JJ, Quinonez SC, Razumilava N, Soyster B, Smith YR, Vander Lugt MT, Wyckoff J.   +6 more
europepmc   +1 more source