Results 251 to 260 of about 337,826 (349)

Antisense-mediated decrease in DNA ligase III expression results in reduced mitochondrial DNA integrity [PDF]

, 2001
Uma Lakshmipathy
openalex   +1 more source

Bioinspired Claw‐Engaged Adhesive Microparticles Armed with γGC Alleviate Ulcerative Colitis via Targeted Suppression of Macrophage Ferroptosis

Advanced Science, EarlyView.
γGC deficiency in ulcerative colitis drives macrophage ferroptosis‐mediated inflammation. Claw‐engaged microparticles armed with γGC (γGC‐MPs) enhance lesion targeting, promoting localized γGC release and tissue uptake. On the cover, Monkey King (Macrophages) was bound by the Immortal‐Binding Rope and subsequently sealed beneath the Five‐Fingered ...
Rong Wang, Jianwei Zhu, Jinyi Zhou, Jinyang Li, Min Wang, Yuqi Wu, Danshan Zhao, Xiancheng Chen, Xiaoyuan Chen, Yuetong Wang, Jianhua Zou   +10 more
wiley   +1 more source

Molecular docking analysis of DNA ligase from Staphylococcus aureus with identical polysaccharides. [PDF]

Bioinformation, 2020
Roy A, Sleeba AV, Joy R, Rajagopal P.
europepmc   +1 more source

Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. [PDF]

J Biol Chem, 2021
Rashid I, Hammel M, Sverzhinsky A, Tsai MS, Pascal JM, Tainer JA, Tomkinson AE.   +6 more
europepmc   +1 more source

Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis

, 2000
Claus Storgaard Sørensen, Claudia Lukas, Edgar R. Kramer, Jan‐Michael Peters, Jiří Bártek, Jiří Lukáš   +5 more
openalex   +1 more source

Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I [PDF]

, 2001
Francisco J. López de Saro, Mike O’Donnell   +1 more
openalex   +1 more source

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining. [PDF]

Nat Commun
Stinson BM, Carney SM, Walter JC, Loparo JJ.   +3 more
europepmc   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage. [PDF]

Mutagenesis, 2020
Tang Q, Kamble P, Çağlayan M.
europepmc   +1 more source