Results 281 to 290 of about 2,416,649 (374)

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

Structural role for DNA Ligase IV in promoting the fidelity of non-homologous end joining. [PDF]

Nat Commun
Stinson BM, Carney SM, Walter JC, Loparo JJ.   +3 more
europepmc   +1 more source

Inhibiting NAD⁺-dependent DNA ligase activity with 2-(cyclopentyloxy)-5′-deoxyadenosine (CPOdA) offers a new tool for DNA replication and repair studies in the model archaeonHaloferax volcanii [PDF]

, 2015
Xavier Giroux, Stuart A. MacNeill
openalex   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Selective inhibition of DNA ligase IV provides additional efficacy to the treatment of anaplastic thyroid cancer. [PDF]

Front Oncol
Sriramareddy SN, Jamakhani M, Vilanova L, Brossel H, Staumont B, Hamaidia M.   +5 more
europepmc   +1 more source

DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage. [PDF]

Mutagenesis, 2020
Tang Q, Kamble P, Çağlayan M.
europepmc   +1 more source

Enzymatic breakage and joining of deoxyribonucleic acid. IV. DNA synthesis in E. coli infected with ligase-negative mutants of phage T4.

, 1968
Yukito Masamune, C C Richardson
openalex   +2 more sources

Biochemical and Genetic Analysis of the Four DNA Ligases of Mycobacteria [PDF]

, 2004
Chunling Gong, Alexandra Martins, Paola Bongiorno, Michael S. Glickman, Stewart Shuman   +4 more
openalex   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

Impact of DNA ligase 1 and IIIα interactions with APE1 and polβ on the efficiency of base excision repair pathway at the downstream steps. [PDF]

J Biol Chem
Almohdar D, Murcia D, Tang Q, Ortiz A, Martinez E, Parwal T, Kamble P, Çağlayan M.   +7 more
europepmc   +1 more source