Results 321 to 330 of about 337,826 (349)

DNA ligases and ligase-based technologies

Clinical and Applied Immunology Reviews, 2001
Abstract DNA ligases catalyze the strand joining reaction at a nick junction. The requirement of base-pair complementarity at the nick junction has been explored for development of ligase-based technologies for mutation detection. In oligonucleotide ligation assay (OLA), two DNA probes complementary to the target sequence are joined by DNA ligase ...
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1 DNA Ligases

1982
Publisher Summary DNA ligases refer to enzymes that catalyze the formation of a phosphodiester linkage between DNA chains. DNA ligases are essential reagents in studies on nucleic acid structure and metabolism. Their value derives from the specificity of the reaction and their ability to join polynucleotide chains covalently.
Charles C. Richardson, M J Engler
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DNA Ligase: Structure, Mechanism, and Function

Science, 1974
DNA ligase of E. coli is a single polypeptide of molecular weight 75,000. The comparable T4-induced enzyme is somewhat smaller (63,000 to 68,000). Both enzymes catalyze the synthesis of phosphodiester bonds between adjacent 5′-phosphoryl and 3′-hydroxyl groups in nicked duplex DNA, coupled to the cleavage of the ...
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Eukaryotic DNA Ligases and DNA Repair

1998
The correct joining of appropriate DNA ends is a fundamental step in many important reactions within the cell and a number of enzymes have been identified which perform these end-joining reactions. Some enzymes execute a ligation step as an intermediate of their overall reaction mechanism; DNA topoisomerases are a prime example of this type of activity
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E3 ligase ligand chemistries: from building blocks to protein degraders

Chemical Society Reviews, 2022
Izidor Sosi, Aleša Bricelj, Christian Steinebach   +2 more
exaly  

DNA Ligases

2005
A Montecucco, R Rossi
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E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

Frontiers in Chemistry, 2021
Aleša Bricelj, Christian Steinebach, Michael Gütschow   +2 more
exaly  

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

Chemical Society Reviews, 2022
Claudia J Diehl, Alessio Ciulli
exaly  

SCF ubiquitin ligase-targeted therapies

Nature Reviews Drug Discovery, 2014
Julia K Pagan, Michele Pagano
exaly  

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Nature, 2014
Eric S Fischer, Michael B Stadler, Simone Cavadini   +2 more
exaly