Results 41 to 50 of about 226,967 (304)

Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase

Scientific Reports, 2021
DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure.
Jolyn Pan, Kjersti Lian, Aili Sarre, Hanna-Kirsti S. Leiros, Adele Williamson   +4 more
doaj   +1 more source

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells [PDF]

, 2011
Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis.
Geacintov, Nicholas E., Tateishi, Satoshi, D'Andrea Alan, Jungmin Kim, Reißner Thomas, Goren, Zohar, Peter H L Krijger, Zvi Livneh, Hendel Ayal, Langerak, Petra, Alan D'Andrea, Kyungjae Myung, Petra Langerak, Nicholas E. Geacintov, Zohar Goren, Satoshi Tateishi, Myung Kyungjae, Goren Zohar, Kim, Jungmin, Jacobs, Heinz, Reißner, Thomas, Nicholas E Geacintov, Jacobs Heinz, Hendel, Ayal, Lee Kyoo-young, Livneh Zvi, Kyoo-young Lee, Diamant, Noam, Geacintov Nicholas E., Krijger, Peter H. L., Peter H. L. Krijger, Noam Diamant, Kim Jungmin, Carell Thomas, Heinz Jacobs, Carell, Thomas, D'Andrea, Alan, Ayal Hendel, Thomas Reissner, Tateishi Satoshi, Myung, Kyungjae, D'Andrea, Alan, Krijger Peter H. L., Lee, Kyoo-young, Thomas Carell, Diamant Noam, Livneh, Zvi, Langerak Petra   +47 more
core   +1 more source

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
core   +1 more source

Rat liver DNA ligases [PDF]

European Journal of Biochemistry, 1992
A novel form of rat liver DNA ligase (molecular mass 100 kDa) can be differentiated from DNA ligase I by several biochemical parameters. It is a more heat‐labile enzyme and unable to join bluntended DNA, even in the presence of poly(ethylene glycol) concentrations which stimulate such joining by DNA ligase I and T4 DNA ligase.
R H Elder, A Montecucco, G Ciarrocchi, J M Rossignol   +3 more
openaire   +3 more sources

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.

PLoS ONE, 2013
Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are two major pathways for repairing DNA double-strand breaks (DSBs); however, their respective roles in human somatic cells remain to be elucidated.
Aya Kurosawa, Shinta Saito, Sairei So, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi, Haruka Watabe, Noritaka Adachi   +6 more
doaj   +1 more source

PCNA and XPF cooperate to distort DNA substrates [PDF]

, 2009
XPF is a structure-specific endonuclease that preferentially cleaves 3' DNA flaps during a variety of repair processes. The crystal structure of a crenarchaeal XPF protein bound to a DNA duplex yielded insights into how XPF might recognise branched DNA ...
J. Carlos Penedo, White, Malcolm F, Timothy D. Craggs, Penedo, J.C., Craggs, T.D., Penedo, Carlos, Richard D. Hutton, Hutton, R.D., Malcolm F. White, Richard D. Hutton, Hutton, Richard David, Craggs, Timothy David, White, M.F.   +12 more
core   +1 more source

DNA Ligase I Is Not Essential for Mammalian Cell Viability

Cell Reports, 2014
Summary: Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability.
Li Han, Shahnaz Masani, Chih-lin Hsieh, Kefei Yu   +3 more
doaj   +1 more source

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells

, 2005
Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström, Hammarström, L,, Lahdesmaki, A, Aleksi Lähdesmäki, Wei Zhou, Andrew R. Gennery, Jones, AM, Michael R. Ehrenstein, Pan-Hammarstrom, Q, Hammarstrom, L, Zhou, W, Gennery, AR, Ehrenstein, MR, Anne-Marie Jones, Richard A. Gatti, Gatti, RA, Qiang Pan-Hammarström   +16 more
core   +1 more source

The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. [PDF]

PLoS ONE, 2016
DNA ligases are essential both to in vivo replication, repair and recombination processes, and in vitro molecular biology protocols. Prior characterization of DNA ligases through gel shift assays has shown the presence of a nick site to be essential for ...
Robert J Bauer, Thomas C Evans, Gregory J S Lohman   +2 more
doaj   +1 more source

Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy

Cell Division, 2007
Recent investigation of Cullin 4 (CUL4) has ushered this class of multiprotein ubiquitin E3 ligases to center stage as critical regulators of diverse processes including cell cycle regulation, developmental patterning, DNA replication, DNA damage and ...
Zhang Hui, Higa Leigh
doaj   +1 more source