Results 41 to 50 of about 1,712,707 (295)

PCNA Ubiquitination Is Important, But Not Essential for Translesion DNA Synthesis in Mammalian Cells [PDF]

, 2011
Translesion DNA synthesis (TLS) is a DNA damage tolerance mechanism in which specialized low-fidelity DNA polymerases bypass replication-blocking lesions, and it is usually associated with mutagenesis.
Geacintov, Nicholas E., Tateishi, Satoshi, D'Andrea Alan, Jungmin Kim, Reißner Thomas, Goren, Zohar, Peter H L Krijger, Zvi Livneh, Hendel Ayal, Langerak, Petra, Alan D'Andrea, Kyungjae Myung, Petra Langerak, Nicholas E. Geacintov, Zohar Goren, Satoshi Tateishi, Myung Kyungjae, Goren Zohar, Kim, Jungmin, Jacobs, Heinz, Reißner, Thomas, Nicholas E Geacintov, Jacobs Heinz, Hendel, Ayal, Lee Kyoo-young, Livneh Zvi, Kyoo-young Lee, Diamant, Noam, Geacintov Nicholas E., Krijger, Peter H. L., Peter H. L. Krijger, Noam Diamant, Kim Jungmin, Carell Thomas, Heinz Jacobs, Carell, Thomas, D'Andrea, Alan, Ayal Hendel, Thomas Reissner, Tateishi Satoshi, Myung, Kyungjae, D'Andrea, Alan, Krijger Peter H. L., Lee, Kyoo-young, Thomas Carell, Diamant Noam, Livneh, Zvi, Langerak Petra   +47 more
core   +2 more sources

A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology [PDF]

, 2010
Conventional drug design embraces the "one gene, one drug, one disease" philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery.
Chen Zhijun, Rommie E. Amaro, Wunder Frank, Michael D. Urbaniak, Philip E. Bourne, Amaro, Rommie E., McCammon, J. Andrew, Urbaniak, Michael D., Michael D Urbaniak, Lei Xie, Michael A J Ferguson, Wunder, Frank, Ferguson Michael A. J., Jacob D. Durrant, Jacob D Durrant, Di Guilmi, Anne Marie, Zhijun Chen, Haapalainen Antti, Urbaniak Michael D., McCammon J. Andrew, J Andrew McCammon, Durrant, Jacob D., Xie, Lei, Rommie E Amaro, Chen, Zhijun, Ferguson, Michael A. J.; id_orcid, Frank Wunder, Amaro Rommie E., Bourne Philip E., Antti Haapalainen, Durrant Jacob D., J. Andrew McCammon, Di Guilmi Anne Marie, Michael A. J. Ferguson, Xie Lei, Bourne, Philip E., Ferguson, Michael A. J., Haapalainen, Antti, Anne Marie Di Guilmi, Philip E Bourne   +39 more
core   +4 more sources

The phage T4 DNA ligase mediates bacterial chromosome DSBs repair as single component non-homologous end joining

Synthetic and Systems Biotechnology, 2019
DNA double-strand breaks (DSBs) are one of the most lethal forms of DNA damage that is not efficiently repaired in prokaryotes. Certain microorganisms can handle chromosomal DSBs using the error-prone non-homologous end joining (NHEJ) system and ...
Tianyuan Su, Fapeng Liu, Yizhao Chang, Qi Guo, Junshu Wang, Qian Wang, Qingsheng Qi   +6 more
doaj   +1 more source

Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase

Scientific Reports, 2021
DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure.
Jolyn Pan, Kjersti Lian, Aili Sarre, Hanna-Kirsti S. Leiros, Adele Williamson   +4 more
doaj   +1 more source

SUMO chain-induced dimerization activates RNF4 [PDF]

, 2014
Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis.
Hay, Ronald T, Rojas-Fernandez, Alejandro, Hattersley, Neil, Plechanovová, Anna, Tatham, Michael H, Jaffray, Ellis   +5 more
core   +1 more source

Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]

, 2012
Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Joanna Kaminska, Łukasiak, Katarzyna, Riezman, Howard, Howard Riezman, Katarzyna Łukasiak, Katarzyna Jarmoszewicz, Jarmoszewicz, Katarzyna, Kaminska, Joanna   +7 more
core   +3 more sources

Rat liver DNA ligases [PDF]

European Journal of Biochemistry, 1992
A novel form of rat liver DNA ligase (molecular mass 100 kDa) can be differentiated from DNA ligase I by several biochemical parameters. It is a more heat‐labile enzyme and unable to join bluntended DNA, even in the presence of poly(ethylene glycol) concentrations which stimulate such joining by DNA ligase I and T4 DNA ligase.
R H Elder, A Montecucco, G Ciarrocchi, J M Rossignol   +3 more
openaire   +3 more sources

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.

PLoS ONE, 2013
Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are two major pathways for repairing DNA double-strand breaks (DSBs); however, their respective roles in human somatic cells remain to be elucidated.
Aya Kurosawa, Shinta Saito, Sairei So, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi, Haruka Watabe, Noritaka Adachi   +6 more
doaj   +1 more source

A viral ubiquitin ligase has substrate preferential SUMO targeted ubiquitin ligase activity that counteracts intrinsic antiviral defence [PDF]

, 2011
Intrinsic antiviral resistance represents the first line of intracellular defence against virus infection. During herpes simplex virus type-1 (HSV-1) infection this response can lead to the repression of viral gene expression but is counteracted by the ...
Delphine Cuchet-Lourenço, Roger D Everett, Roger D. Everett, Boutell Chris, McFarlane Steven, Cuchet, D., Mandy Glass, Steven McFarlane, Cuchet-Lourenço Delphine, Chris Boutell, Glass, M., Vanni, E., Orr Anne, Everett Roger D., McFarlane, S., Everett, R.D., Glass Mandy, Vanni Emilia, Boutell, C., Emilia Vanni, Anne Orr, Orr, A.   +21 more
core   +1 more source

DNA Ligase I Is Not Essential for Mammalian Cell Viability

Cell Reports, 2014
Summary: Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability.
Li Han, Shahnaz Masani, Chih-lin Hsieh, Kefei Yu   +3 more
doaj   +1 more source