Results 51 to 60 of about 1,333 (119)
Mammalian DNA ligases. Biosynthesis and intracellular localization of DNA ligase I.
Journal of Biological Chemistry, 1990 Mammalian DNA ligase I is presumed to act in DNA replication. Rabbit antibodies against the homogeneous enzyme from calf thymus inhibited DNA ligase I activity and consistently recognized a single polypeptide of 125 kDa when cells from an established bovine kidney cell line (MDBK) were lysed rapidly by a variety of procedures and subjected to ...
D D, Lasko, A E, Tomkinson, T, Lindahl
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Mammalian DNA ligases. Catalytic domain and size of DNA ligase I.
Journal of Biological Chemistry, 1990 DNA ligase I is the major DNA ligase activity in proliferating mammalian cells. The protein has been purified to apparent homogeneity from calf thymus. It has a monomeric structure and a blocked N-terminal residue. DNA ligase I is a 125-kDa polypeptide as estimated by sodium dodecyl sulfate-gel electrophoresis and by gel chromatography under denaturing
A E, Tomkinson +3 more
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Case Report: Hypomorphic Ligase 4 deficiency – a paradigm of immunodysregulation
Frontiers in ImmunologyDNA Ligase 4 is critical to nonhomologous end joining, necessary for V(D)J recombination in T and B cell development. Ligase 4 deficiency is a rare autosomal recessive disorder caused by hypomorphic mutations in the DNA Ligase 4 gene, that can lead to a ...
Catarina Andrade +8 more
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Biology Direct, 2009 Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV ...
Koonin Eugene V, Yutin Natalya
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BMC ChemistryDental caries is a disease of tooth tissue that can lead to complications, with Enterococcus faecalis being one of the Gram-positive bacteria that plays a crucial role in the infection process.
Devi Meliani +2 more
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The Human Adenovirus Type 5 E4orf6/E1B55K E3 Ubiquitin Ligase Complex Can Mimic E1A Effects on E2F
mSphere, 2016 The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny.
Frédéric Dallaire +5 more
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PLoS Pathogens, 2015 Uncontrolled immune responses to intracellular DNA have been shown to induce autoimmune diseases. Homeostasis regulation of immune responses to cytosolic DNA is critical for limiting the risk of autoimmunity and survival of the host. Here, we report that
Yanming Wang +9 more
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Targeted Protein Degradation Strategies in DNA Virus Research
VirusesDNA viruses rely extensively on host cellular machinery, including replication factors and transcriptional systems, to persist after infection. These mechanisms make studying and targeting DNA viral proteins challenging, as they also play key roles in ...
Michael Lam +3 more
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Frontiers in Cellular and Infection Microbiology, 2022 Elisa Azuara-Liceaga +14 more
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