Results 31 to 40 of about 1,333 (119)
USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A
Nature Communications, 2018 BRCA1 ligase activity is tightly regulated to maintain genome stability and confer DNA double strand repair. Here the authors identify USP48 as a H2A deubiquitinating enzyme that acts as a BRCA1 E3 ligase antagonist and characterize its role during DNA ...
Michael Uckelmann +6 more
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Effects of DNA-binding drugs on T4 DNA ligase [PDF]
Biochemical Journal, 1990 A number of DNA intercalating and externally binding drugs have been found to inhibit nick sealing, cohesive and blunt end ligation, AMP-dependent DNA topoisomerization and EDTA-induced DNA nicking mediated by bacteriophage T4 DNA ligase. The inhibition seems to arise from drug-substrate interaction so that formation of active DNA-Mg2(+)-AMP-enzyme ...
A Montecucco +4 more
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Interactome analysis and docking site prediction of DNA X-ray repair cross-complementing protein (XRCC) in Arabidopsis thaliana [PDF]
Network Biology, 2020 There are seven homologs in eukaryotic RAD51 gene family which are conserved among animals and plants, and those are RAD51, DMC1, RAD51c, XRCC3, RAD51b, RAD51d and XRCC2.
Mohamed Ragab Abdel Gawwad +2 more
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ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.
PLoS Biology, 2015 Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid ...
Marcelino Bermúdez-López +11 more
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Case Report: Wide Spectrum of Manifestations of Ligase IV Deficiency: Report of 3 Cases
Frontiers in Immunology, 2022 DNA ligase IV deficiency is a rare autosomal recessive disorder associated with impaired DNA repair mechanisms. Most patients with DNA repair defects present with neurologic deficits, combined immunodeficiency, bone marrow failure, and/or hematologic ...
Ana Costa e Castro +10 more
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DNA Ligases: Progress and Prospects [PDF]
Journal of Biological Chemistry, 2009 DNA ligases seal 5'-PO4 and 3'-OH polynucleotide ends via three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes.
openaire +2 more sources
Bio-Protocol, 2017 We previously reported that oxidized nucleotide insertion by DNA polymerase β (pol β) can confound the DNA ligation step during base excision repair (BER) (Çağlayan et al., 2017).
Melike Çağlayan, Samuel Wilson
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Plasmodium DNA ligase I is essential for parasite blood- and liver-stage development
mSphereDNA ligases are a fundamental class of enzymes required for DNA replication and repair. They catalyze the formation of phosphodiester bonds, specifically at single-strand breaks in double-stranded DNA.
Eisha Pandey +4 more
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Closing the gap on DNA ligase [PDF]
Structure, 1996 The crystal structure of T7 DNA ligase complexed with ATP illuminates the mechanism of covalent catalysis by a superfamily of nucleotidyl transferases that includes the ATP-dependent polynucleotide ligases and the GTP-dependent mRNA capping enzymes.
openaire +2 more sources
The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex
Cell Reports, 2019 Summary: Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and inflammation in immunocompetent people and life-threatening disease upon immunosuppression.
Michael Bauer +8 more
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