Results 11 to 20 of about 350,926 (202)

Horizontal acquisition of a DNA ligase improves DNA damage tolerance in eukaryotes [PDF]

Nature Communications, 2023
Bdelloid rotifers are part of the restricted circle of multicellular animals that can withstand a wide range of genotoxic stresses at any stage of their life cycle. In this study, bdelloid rotifer Adineta vaga is used as a model to decipher the molecular
Emilien Nicolas, Paul Simion, Marc Guérineau, Matthieu Terwagne, Mathilde Colinet, Julie Virgo, Maxime Lingurski, Anaïs Boutsen, Marc Dieu, Bernard Hallet, Karine Van Doninck   +10 more
doaj   +2 more sources

The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination. [PDF]

PLoS ONE, 2023
DNA Ligase IV is responsible for the repair of DNA double-strand breaks (DSB), including DSBs that are generated during V(D)J recombination. Like other DNA ligases, Ligase IV contains a catalytic core with three subdomains-the DNA binding (DBD), the ...
Vidyasagar Malashetty, Audrey Au, Jose Chavez, Mary Hanna, Jennifer Chu, Jesse Penna, Patricia Cortes   +6 more
doaj   +2 more sources

Plasmodium DNA ligase I is essential for parasite blood- and liver-stage development [PDF]

mSphere
DNA ligases are a fundamental class of enzymes required for DNA replication and repair. They catalyze the formation of phosphodiester bonds, specifically at single-strand breaks in double-stranded DNA.
Eisha Pandey, Shivani Mishra, Aastha Varshney, Saman Habib, Satish Mishra   +4 more
doaj   +2 more sources

Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]

DNA Repair, 2006
DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J, Jeggo, Penny, Marchetti, Caterina, Odreman, Federico, Vindigni, Alessandro, Walker, Sarah A   +5 more
core   +4 more sources

In vitro and in silico characterization of Crocatin A from red betel leaves: targeting DNA gyrase B and DNA ligase of Enterococcus faecalis with ADMET-based druglikeness analysis [PDF]

BMC Chemistry
Dental caries is a disease of tooth tissue that can lead to complications, with Enterococcus faecalis being one of the Gram-positive bacteria that plays a crucial role in the infection process.
Devi Meliani, Trisna Yuliana, Dikdik Kurnia   +2 more
doaj   +2 more sources

The Sole DNA Ligase in Entamoeba histolytica Is a High-Fidelity DNA Ligase Involved in DNA Damage Repair [PDF]

Frontiers in Cellular and Infection Microbiology, 2018
The protozoan parasite Entamoeba histolytica is exposed to reactive oxygen and nitric oxide species that have the potential to damage its genome. E. histolytica harbors enzymes involved in DNA repair pathways like Base and Nucleotide Excision Repair. The
Elisa Azuara-Liceaga, Abigail Betanzos, Abigail Betanzos, Cesar S. Cardona-Felix, Cesar S. Cardona-Felix, Elizabeth J. Castañeda-Ortiz, Helios Cárdenas, Rosa E. Cárdenas-Guerra, Guillermo Pastor-Palacios, Guillermina García-Rivera, David Hernández-Álvarez, Carlos H. Trasviña-Arenas, Corina Diaz-Quezada, Esther Orozco, Luis G. Brieba   +14 more
doaj   +2 more sources

The decrease in Rad51 and DNA ligase IV nuclear protein expression in Msh2 knockdown HC11 cells induced the low CRISPR/Cas9-mediated knock-in efficiency at the β-casein gene locus [PDF]

Animal Bioscience
Objective Successful gene editing technology is crucial in molecular biology and related fields. An essential part of an efficient knock-in system is increasing homologous recombination (HR) efficiency in the double-strand break (DSB) repair pathways ...
Ga-Yeon Kim, Man-Jong Kang
doaj   +2 more sources

Corrigendum: The sole DNA ligase in Entamoeba histolytica is a high-fidelity DNA ligase involved in DNA damage repair [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Elisa Azuara-Liceaga, Abigail Betanzos, Abigail Betanzos, Cesar S. Cardona-Felix, Cesar S. Cardona-Felix, Elizabeth J. Castañeda-Ortiz, Helios Cárdenas, Rosa E. Cárdenas-Guerra, Guillermo Pastor-Palacios, Guillermina García-Rivera, David Hernández-Álvarez, Carlos H. Trasviña-Arenas, Corina Diaz-Quezada, Esther Orozco, Luis G. Brieba   +14 more
doaj   +2 more sources

The discovery of the mechanisms of biological synthesis of nucleic acids: 1959 Nobel laureates S. Ochoa and A. Kornberg [PDF]

The Ukrainian Biochemical Journal, 2021
Alongside the chemical and physical research of nucleic acids in the 1940s-50s, the mechanisms of their biosynthesis were investigated. Thus, in 1959, Severo Ochoa and Arthur Kornberg were awarded the Nobel Prize in Physiology or Medicine for the ...
O. P. Matyshevska, V. M. Danilova, S. V. Komisarenko   +2 more
doaj   +1 more source

MAMMALIAN DNA LIGASES [PDF]

Annual Review of Biochemistry, 1992
DNA LIGASE I .... ... ....... ...... . . . . . .. . . . .. ........ . 255 Structure. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 Gene Structure and Chromosome Mapping . . . . ......... . . . . . .. . . . . .
T, Lindahl, D E, Barnes
openaire   +3 more sources