Results 161 to 170 of about 182,062 (331)

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

The FGF13‐Caveolin‐1 Axis: A Key Player in the Pathogenesis of Doxorubicin‐ and D‐Galactose‐Induced Premature Cardiac Aging

Advanced Science, EarlyView.
The FGF13 level is significantly downregulated in premature aging murine hearts subject to D‐galactose and Doxorubicin. FGF13 overexpression and deficiency exacerbated and alleviated Doxorubicin/D‐galactose‐induced myocardial aging characteristics and functional impairment, respectively.
Enzhao Shen, Yuecheng Wu, Weijian Ye, Sihang Li, Junjie Zhu, Meifan Jiang, Zhicheng Hu, Gaoyong Cao, Xiaojing Yi, Fan Li, Zhouhao Tang, Xiaokun Li, Kwang Youl Lee, Litai Jin, Xu Wang, Weitao Cong   +15 more
wiley   +1 more source

T4 DNA ligase is more than an effective trap of cyclized dsDNA [PDF]

T4 DNA ligase is used in standard cyclization assays to trap double-stranded DNA (dsDNA) in low-probability, cyclic or highly bent conformations. The cyclization probability, deduced from the relative yield of cyclized product, can be used in conjunction
Balaeff, Bauer, Benham, Bloomfield, Bouchiat, Bustamante, Cherpepanov, Chongli Yuan, Cloutier, Cloutier, Crothers, Du, Elizabeth Rhoades, Friedman, Hagerman, Hagerman, Hao, Holz, Huimin Chen, Jean, Kahn, Lee, Lehman, Liu, Lowary, Lynden A. Archer, Magde, Millar, Park, Rachofsky, Rai, Rhoades, Richmond, Rossi, SantaLucia, Schallhorn, Shimada, Shore, Singleton, Stivers, Su, Subramanya, Thastrom, Wang, Ward, Wiggins, Xiong Wen Lou, Yahovchuk, Yan, Yan, Yang, Yang, Yuan, Zhang   +53 more
core   +2 more sources

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

Continuous-time random walk model for the diffusive motion of helicases [PDF]

arXiv
DNA helicases are molecular motors that use the energy from ATP hydrolysis to move along DNA, promoting the unwinding or rewinding of the double helix. Here, we use magnetic and optical tweezers to track the motion of three helicases, gp41, RecQ, and RecG, while they unwind or rewind a DNA hairpin.
arxiv  

Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis. [PDF]

, 2020
Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis.
Cuevas-Mora, Karina, Romero, Freddy, Roque, Willy   +2 more
core   +1 more source

The MdHB7L–MdICE1L–MdHOS1 Module Fine‐Tunes Apple Cold Response via CBF‐Dependent and CBF‐Independent Pathways

Advanced Science, EarlyView.
In early cold response, MdICE1L utilizes MdHB7L as a cofactor to facilitate the transcriptional activation of MdCBFs, thereby activating cold signaling rapidly and strongly. Subsequently, MdICE1L is degraded by MdHOS1. Meanwhile, MdHB7L is released and accumulates.
Jie Yang, Na Li, Ming Li, Ran Yi, Lina Qiu, Kangning Wang, Shuang Zhao, Fengwang Ma, Ke Mao   +8 more
wiley   +1 more source

Complex rheology of condensin in entangled DNA [PDF]

arXiv
Structural-Maintenance-of-Chromosome (SMC) complexes such as condensins are well-known to dictate the folding and entanglement of interphase and mitotic chromosomes. However, their role in modulating the rheology and viscoelasticity of entangled DNA is not fully understood.
arxiv  

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Trimerization of 1,2‐Diaminocyclohexane Catalyzed by a Metal–Organic Cage Tandem Catalyst with Dual Biomimetic Active Sites

Advanced Science, EarlyView.
Dual biomimetic active sites, i.e., mononuclear {ZnII(L)(H2O)} and dinuclear {L2ZnII(CHO2)(OH)ZnIIL2}, have been successfully intergrated into a metal–organic cage, Zn20‐MOC. These two different active sites in Zn20‐MOC catalyze different steps of cascade trimerization of 1,2‐diaminocyclohexane. The mononuclear {ZnII(L)(H2O)} site catalyzes the initial
Xiao‐Jun Chai, Zhu Zhuo, Zi‐Ang Nan, Shiqiang Mu, Zhong‐Yu Peng, Ting Chen, Wei Wang, Li‐Feng Lin, Xi Meng, Mao‐Chun Hong, You‐Gui Huang   +10 more
wiley   +1 more source