Dystonia: Insights into Mechanisms and Novel Therapeutics. [PDF]
Dzinovic I, Zech M.
europepmc +1 more source
Ligase IV, DNA, ATP-dependent (LIG4); BTB domain containing 2 (BTBD2); high mobility group AT-hook 2 (HMGA2); regulator of telomere elongation helicase 1 (RTEL1); coiled-coil domain containing 26 (CCDC26) [PDF]
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We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source
Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma. [PDF]
Liu FP +8 more
europepmc +1 more source
In Bacteria, the replicative DNA ligase is NAD‐dependent. However, some bacteria possess accessory ATP‐dependent DNA ligases (ADLs) which vary in size and domain organization. Phylogenomic analyses of bacterial ADLs reveal that types Lig B, Lig C and Lig D have descended from a common ancestor, while Lig E was transferred in a separate event, possibly from a bacteriophage. For details, see the article by Williamson et al. on pp. 274‐290 of this issue. [PDF]
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Ribozyme für die RNA‐katalysierte Methylierung und Markierung von RNA
Ribozyme sind vielseitige Werkzeuge für die präzise Modifikation von RNA. Das Reaktionsspektrum in‐vitro‐selektierter Ribozyme reicht vom Einbau funktioneller Gruppen und Fluorophoren bis zu natürlichen RNA‐Methylierungen. Dieser Übersichtsartikel präsentiert Cofaktor‐abhängige Ribozyme für die positionsgenaue Markierung und Modifikation von RNA ...
Carolin P. M. Scheitl +1 more
wiley +1 more source
Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies. [PDF]
Shen T +7 more
europepmc +1 more source
Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl +1 more
wiley +1 more source

