Results 211 to 220 of about 145,020 (273)

Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu, Chiharu Nakasu, Yu Saito, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Hiroki Teraoku, Mitsuo Shimada   +7 more
wiley   +1 more source

A tailored enzyme cascade facilitates DNA-encoded library technology and gives access to a broad substrate scope

Buller R, Schaub D, Lessing A, Meyer F, Eichenberger M, von Haugwitz G, Stockinger P, Gloger A, Scheuermann J.   +8 more
europepmc   +1 more source

Targeting the cGAS-STING Pathway to Modulate Immune Inflammation in Diabetes and Cardiovascular Complications: Mechanisms and Therapeutic Insights. [PDF]

Curr Issues Mol Biol
Cai G, Zhang X, Jiao J, Du W, Yan M.
europepmc   +1 more source

Engineering Lanthanide Metal‐Organic Framework Nuclease Nanozymes: Unveiling Affinity‐Driven DNA Hydrolysis

Aggregate, EarlyView.
Affinity‐engineered lanthanide MOFs overturn the Lewis acidity paradigm: DNA hydrolysis efficiency rises with atomic number despite weaker binding. Yb‐BDC achieves record DNA‐cleaving activity yet low BNPP activity, revealing a critical binding–release cycle.
Zhiwen Gan, Long Yu, Yongzhen Liu, Yumin Feng, Jiyu Tong, Yuxiu Xiao   +5 more
wiley   +1 more source

Therapeutic Targeting of Protein Lysine and Arginine Methyltransferases: Principles and Strategies for Inhibitor Design. [PDF]

Int J Mol Sci
Micallef I, Baron B.
europepmc   +1 more source

Development of an efficient mice model of cancer‐associated cardiac cachexia

Animal Models and Experimental Medicine, EarlyView.
This work establishes a preclinical framework for targeting ubiquitin pathways to mitigate the morbidity of cancer‐related cardiopathy. Our integrated approach delineates a hierarchical progression from subcellular dysfunction to macroscopic cardiac deterioration. These findings mechanistically link tumor‐induced cachexia to cardiac dysfunction through
Shijie Xiong, Huiting Zheng, Teng Wu, Jing Tan, Tongsheng Huang, Conghui Shen, Yuanjun Ji, Mengying Liu, Junhong Wan, Weibin Cai   +9 more
wiley   +1 more source

Targeted protein degradation of HSP90 and associated proteins for cancer therapy <i>via</i> PROTACs and beyond. [PDF]

RSC Med Chem
Kumar G, Tyagi G, Monga V.
europepmc   +1 more source

Advances in miRNA research: Unraveling the complexities of gene regulation

Animal Models and Experimental Medicine, EarlyView.
Overview of miRNA‐mediated regulation in key biological processes. This illustration offers a comprehensive view of the diverse functions that microRNAs perform in governing various biological processes, highlighting their profound significance within the complex web of gene expression and cellular function.
Jiawei Zheng, Guoqing Zhang, Linzhu Ren
wiley   +1 more source

Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids. [PDF]

Int J Mol Sci
Sun D, Gokhale V.
europepmc   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source