Thermostable DNA ligases from hyperthermophiles in biotechnology [PDF]
Frontiers in Microbiology, 2023 DNA ligase is an important enzyme ubiquitous in all three kingdoms of life that can ligate DNA strands, thus playing essential roles in DNA replication, repair and recombination in vivo.
Jingru Shi +3 more
doaj +2 more sources
Extraordinarily Stable Hairpin-Based Biosensors for Rapid Detection of DNA Ligases [PDF]
Biosensors, 2023 DNA ligases are essential enzymes involved in DNA replication and repair processes in all organisms. These enzymes seal DNA breaks by catalyzing the formation of phosphodiester bonds between juxtaposed 5′ phosphate and 3′ hydroxyl termini in double ...
Ziang Wu +6 more
doaj +2 more sources
Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase [PDF]
Scientific Reports, 2021 DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure.
Jolyn Pan +4 more
doaj +2 more sources
Comparative analysis of the end-joining activity of several DNA ligases. [PDF]
PLoS ONE, 2017 DNA ligases catalyze the repair of phosphate backbone breaks in DNA, acting with highest activity on breaks in one strand of duplex DNA. Some DNA ligases have also been observed to ligate two DNA fragments with short complementary overhangs or blunt ...
Robert J Bauer +6 more
doaj +2 more sources
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]
DNA Repair, 2006 DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J +5 more
core +5 more sources
Biochemical and Structural Characterisation of DNA Ligases from Bacteria and Archaea. [PDF]
Biosci Rep, 2016 DNA ligases are enzymes that seal breaks in the backbones of DNA, leading to them being essential for the survival of all organisms. DNA ligases have been studied from many different types of cells and organisms and shown to have diverse sizes and ...
Pergolizzi G, Wagner GK, Bowater RP.
europepmc +4 more sources
Naphthalimides Selectively Inhibit the Activity of Bacterial, Replicative DNA Ligases and Display Bactericidal Effects against Tubercle Bacilli [PDF]
Molecules, 2017 The DNA ligases, enzymes that seal breaks in the backbones of DNA, are essential for all organisms, however bacterial ligases essential for DNA replication use β-nicotinamide adenine dinucleotide as their co-factor, whereas those that are essential in ...
Malgorzata Korycka-Machala +6 more
doaj +2 more sources
Plant SUMO E3 Ligases: Function, Structural Organization, and Connection With DNA
Frontiers in Plant Science, 2021 Protein modification by the small ubiquitin-like modifier (SUMO) plays an important role in multiple plant processes, including growth, development, and the response to abiotic stresses.
Laurent Cappadocia, Ivana Smičiklas
exaly +3 more sources
The role of host DNA ligases in hepadnavirus covalently closed circular DNA formation. [PDF]
PLoS Pathogens, 2017 Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence.
Quanxin Long +11 more
doaj +2 more sources
Human DNA ligases in replication and repair. [PDF]
DNA Repair (Amst), 2020 To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex DNA is required during DNA replication and to complete the repair of almost all types of DNA damage. In human cells, this task is accomplished by DNA ligases encoded by three genes, LIG1, LIG3 and LIG4.
Sallmyr A +4 more
europepmc +5 more sources