Results 1 to 10 of about 1,514,296 (280)

The DNA binding domain and the C-terminal region of DNA Ligase IV specify its role in V(D)J recombination.

PLoS ONE, 2023
DNA Ligase IV is responsible for the repair of DNA double-strand breaks (DSB), including DSBs that are generated during V(D)J recombination. Like other DNA ligases, Ligase IV contains a catalytic core with three subdomains-the DNA binding (DBD), the ...
Vidyasagar Malashetty, Audrey Au, Jose Chavez, Mary Hanna, Jennifer Chu, Jesse Penna, Patricia Cortes   +6 more
doaj   +1 more source

RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
Cullin-RING E3-Ligases (CRLs), the largest family of E3 ubiquitin-Ligases, regulate diverse cellular processes by promoting ubiquitination of target proteins.
Batool Ossareh-Nazari, Anthi Katsiarimpa, Jorge Merlet, Lionel Pintard   +3 more
doaj   +1 more source

DNA Ligases: Progress and Prospects [PDF]

Journal of Biological Chemistry, 2009
DNA ligases seal 5'-PO4 and 3'-OH polynucleotide ends via three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes.
openaire   +2 more sources

Multifaceted roles of SUMO in DNA metabolism

Nucleus
Sumoylation, a process in which SUMO (small ubiquitin like modifier) is conjugated to target proteins, emerges as a post-translational modification that mediates protein−protein interactions, protein complex assembly, and localization of target proteins.
Yee Mon Thu
doaj   +1 more source

Cullin 3 as a novel target in diverse pathologies

Redox Biology, 2013
Recent evidence suggests that the malfunctioning disposal system of cell protein called ubiquitin–proteasome system (UPS) plays an important role in the development of disorders, including cancer and neurodegenerative diseases.
Ana Cristina Andérica-Romero, Irma Gabriela González-Herrera, Abel Santamaría, José Pedraza-Chaverri   +3 more
doaj   +1 more source

Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses.

PLoS Pathogens, 2021
Viruses have evolved means to manipulate the host's ubiquitin-proteasome system, in order to down-regulate antiviral host factors. The Vpx/Vpr family of lentiviral accessory proteins usurp the substrate receptor DCAF1 of host Cullin4-RING ligases (CRL4),
Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J O'Reilly, Ludwig Sinn, Olga Ruda, Juri Rappsilber, Christian M T Spahn, Thorsten Mielke, Ian A Taylor, David Schwefel   +12 more
doaj   +1 more source

Targeting E3 ubiquitin ligases: Mechanistic breakthroughs and novel clinical translation pathways for tumor radioimmunotherapy

Molecular Cancer
The combination of radiation therapy and immunotherapy has become a cornerstone of modern clinical cancer treatment. However, the inherent radiation resistance of tumors and complex immune evasion mechanisms remain major bottlenecks limiting their long ...
Qian Yang, Xinruo Xing, Yichun Wang, Xiangyi Wang, Yutong Han, Jiaxin Ren, Zhenyong Zhang, Jun Tang, Jianzhu Zhao   +8 more
doaj   +1 more source

Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1

Cell Reports
Summary: Homologous to E6AP C terminus (HECT) ubiquitin ligases play key roles in essential pathways such as DNA repair, cell cycle control, or protein quality control. Tom1 is one of five HECT ubiquitin E3 ligases in budding yeast S.
Katrina Warner, Moritz Hunkeler, Kheewoong Baek, Anna Schmoker, Shourya S. Roy Burman, Daan Overwijn, Cyrus Jin, Katherine A. Donovan, Eric S. Fischer   +8 more
doaj   +1 more source

Closing the gap on DNA ligase [PDF]

Structure, 1996
The crystal structure of T7 DNA ligase complexed with ATP illuminates the mechanism of covalent catalysis by a superfamily of nucleotidyl transferases that includes the ATP-dependent polynucleotide ligases and the GTP-dependent mRNA capping enzymes.
openaire   +2 more sources

The Atypical Occurrence of Two Biotin Protein Ligases in Francisella novicida Is Due to Distinct Roles in Virulence and Biotin Metabolism

mBio, 2015
The physiological function of biotin requires biotin protein ligase activity in order to attach the coenzyme to its cognate proteins, which are enzymes involved in central metabolism.
Youjun Feng, Chui-Yoke Chin, Vandana Chakravartty, Rongsui Gao, Emily K. Crispell, David S. Weiss, John E. Cronan   +6 more
doaj   +1 more source