Results 1 to 10 of about 73,416 (250)

Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]

DNA Repair, 2006
DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J, Jeggo, Penny, Marchetti, Caterina, Odreman, Federico, Vindigni, Alessandro, Walker, Sarah A   +5 more
core   +5 more sources

Bacteriophage origin of some minimal ATP-dependent DNA ligases: a new structure from Burkholderia pseudomallei with striking similarity to Chlorella virus ligase. [PDF]

Sci Rep, 2021
DNA ligases, the enzymes responsible for joining breaks in the phosphodiester backbone of DNA during replication and repair, vary considerably in size and structure.
Pan J, Lian K, Sarre A, Leiros HS, Williamson A.   +4 more
europepmc   +4 more sources

Biochemical and Structural Characterisation of DNA Ligases from Bacteria and Archaea. [PDF]

Biosci Rep, 2016
DNA ligases are enzymes that seal breaks in the backbones of DNA, leading to them being essential for the survival of all organisms. DNA ligases have been studied from many different types of cells and organisms and shown to have diverse sizes and ...
Pergolizzi G, Wagner GK, Bowater RP.
europepmc   +4 more sources

Human DNA ligases in replication and repair. [PDF]

DNA Repair (Amst), 2020
To ensure genome integrity, the joining of breaks in the phosphodiester backbone of duplex DNA is required during DNA replication and to complete the repair of almost all types of DNA damage. In human cells, this task is accomplished by DNA ligases encoded by three genes, LIG1, LIG3 and LIG4.
Sallmyr A, Rashid I, Bhandari SK, Naila T, Tomkinson AE.   +4 more
europepmc   +5 more sources

DNA ligases: progress and prospects. [PDF]

J Biol Chem, 2009
DNA ligases seal 5'-PO4 and 3'-OH polynucleotide ends via three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are essential guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes.
Shuman S.
europepmc   +5 more sources

DNA ligases as therapeutic targets. [PDF]

Transl Cancer Res, 2013
During DNA replication, DNA joining events link Okazaki fragments on the lagging strand. In addition, they are required to repair DNA single- and double-strand breaks and to complete repair events initiated by the excision of mismatched and damaged bases. In human cells, there are three genes encoding DNA ligases.
Tomkinson AE, Howes TR, Wiest NE.
europepmc   +4 more sources

SUMO chain formation is required for response to replication arrest in S. pombe [PDF]

, 2009
SUMO is a ubiquitin-like protein that is post-translationally attached to one or more lysine residues on target proteins. Despite having only 18% sequence identity with ubiquitin, SUMO contains the conserved betabetaalphabetabetaalphabeta fold present in
A Gorg, A Pichler, Andrew Skilton, B Xhemalce, Brenda Mercer, C Hoege, CM Pickart, E Harlow, EA Andrews, Emily Outwin, F al-Khodairy, Felicity Z. Watts, FZ Watts, GR Bylebyl, Gustavo Goldman, H Sun, HD Ulrich, HL Klein, I Matic, J Bahler, J Prudden, JC Ho, JC Ho, Jenny C. Y. Ho, JR Mullen, K Tanaka, KP Bencsath, M Rechsteiner, M Shayeghi, MH Tatham, MH Tatham, O Kerscher, P Bayer, P Stelter, PL Kannouche, RJ Sims 3rd, RT Hay, RT Hay, S Vijay-Kumar, T Caspari, V Lallemand-Breitenbach, Y Takahashi   +41 more
core   +15 more sources

Bacterial DNA ligases [PDF]

Molecular Microbiology, 2001
DNA ligases join breaks in the phosphodiester backbone of DNA molecules and are used in many essential reactions within the cell. All DNA ligases follow the same reaction mechanism, but they may use either ATP or NAD+ as a cofactor. All Bacteria (eubacteria) contain NAD+‐dependent DNA ligases, and the uniqueness of these enzymes to Bacteria makes them ...
Wilkinson, A, Day, J, Bowater, R
openaire   +4 more sources

MAMMALIAN DNA LIGASES [PDF]

Annual Review of Biochemistry, 1992
DNA LIGASE I .... ... ....... ...... . . . . . .. . . . .. ........ . 255 Structure. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255 Gene Structure and Chromosome Mapping . . . . ......... . . . . . .. . . . . .
Deborah E. Barnes, Tomas Lindahl
openaire   +3 more sources

DNA Ligase I, the Replicative DNA Ligase [PDF]

, 2012
Multiple DNA ligation events are required to join the Okazaki fragments generated during lagging strand DNA synthesis. In eukaryotes, this is primarily carried out by members of the DNA ligase I family. The C-terminal catalytic region of these enzymes is composed of three domains: a DNA binding domain, an adenylation domain and an OB-fold domain.
Timothy R.L. Howes, Alan E. Tomkinson
openaire   +3 more sources