Results 1 to 10 of about 52,926 (249)

Prokaryotic DNA Ligases Unwind Superhelical DNA

Biochemical and Biophysical Research Communications, 1996
We have studied the effect on DNA topology of binding of prokaryotic DNA ligases (T4 and E. coli) to superhelical or nicked circular DNA. Performing topoisomerase I-mediated relaxation in the presence of increasing amounts of T4 ligase led to a shift in the topoisomer distribution to increasingly more negative values.
M, Ivanchenko, K, van Holde, J, Zlatanova   +2 more
openaire   +2 more sources

DNA Polymerases and DNA Ligases

2013
DNA polymerase and DNA ligase are ubiquitous enzymes that synthesize complementary DNA strands according to the template DNA and ligate breaks in the backbone structure of DNA, respectively, in living organisms. Multiple enzymes have been identified from each organism, and the functional sharing of these enzymes has been investigated for both DNA ...
Sonoko Ishino, Yoshizumi Ishino
openaire   +1 more source

DNA ligases and ligase-based technologies

Clinical and Applied Immunology Reviews, 2001
Abstract DNA ligases catalyze the strand joining reaction at a nick junction. The requirement of base-pair complementarity at the nick junction has been explored for development of ligase-based technologies for mutation detection. In oligonucleotide ligation assay (OLA), two DNA probes complementary to the target sequence are joined by DNA ligase ...
openaire   +1 more source

Eukaryotic DNA Ligases and DNA Repair

1998
The correct joining of appropriate DNA ends is a fundamental step in many important reactions within the cell and a number of enzymes have been identified which perform these end-joining reactions. Some enzymes execute a ligation step as an intermediate of their overall reaction mechanism; DNA topoisomerases are a prime example of this type of activity
openaire   +1 more source

DNA Ligases

2005
A Montecucco, R Rossi
openaire   +2 more sources

DNA Ligases:  Structure, Reaction Mechanism, and Function

Chemical Reviews, 2006
Alan E Tomkinson, John M Pascal, Tom Ellenberger   +2 more
exaly  

DNA Ligase

RCSB Protein Data Bank, 2004
openaire   +1 more source

DNA Ligase IV

2007
openaire   +2 more sources

Mechanistic Comparison of High-Fidelity and Error-Prone DNA Polymerases and Ligases Involved in DNA Repair

Chemical Reviews, 2006
Marina Bakhtina, Ming-Daw Tsai
exaly  

Human DNA Ligases: A Comprehensive New Look for Cancer Therapy

Medicinal Research Reviews, 2014
Deependra Kumar Singh, Shagun Krishna, Sharat Chandra   +2 more
exaly