Results 111 to 120 of about 382,011 (287)

Epigenome-wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study

, 2021
Thanh T. Hoang
openalex   +2 more sources

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Additional file 5 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

, 2021
Monica Del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matías‐García, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebért, Olli T. Raitakari, Marie Loh, Wolfgang Rathmann, Martina Müller‐Nurasyid, Christian Herder, Michael Roden, Mikko Hurme, Marjo‐Riitta Järvelin, Mika Ala‐Korpela, Jaspal S. Kooner, Annette Peters, Terho Lehtimäki, John C. Chambers, Christian Gieger, Johannes Kettunen, Mélanie Waldenberger   +30 more
openalex   +1 more source

Paving the Way to Elucidate Hg's Role in Tumorigenesis

Advanced Science, EarlyView.
Tumorigenesis can result from diverse environmental carcinogens. Among them, mercury—a lifelong bioaccumulative Group 2B carcinogen—has tumorigenic potential that remains poorly understood due to confounding co‐exposures and limited organ‐specific data.
Shouying Li, Rong Zhong, Zhenyang Yu, Hualing Fu, Jin Chen, Jia Wei, Ningwei Zhao, Le Qu, Tiantian Li, Wenli Tang, Huan Zhong   +10 more
wiley   +1 more source

DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities

Clinical Epigenetics
Abnormal DNA methylation is a hallmark of cancer and a nearly universal feature of melanoma. DNA methylation plays well-appreciated melanoma cell-intrinsic roles, including silencing tumor-suppressor genes, regulating genomic stability, deregulating ...
Maya G. Deshmukh, Veronica T. Brooks, Simon F. Roy, Simon Milette, Marcus Bosenberg, Goran Micevic   +5 more
doaj   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Supplementary Table 2 from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma [PDF]

, 2023
Kelly R. Ostler, Qiwei Yang, Timothy J. Looney, Li Zhang, Aparna Vasanthakumar, Yufeng Tian, Masha Kocherginsky, Stacey L. Raimondi, Jessica G. DeMaio, Helen R. Salwen, Song Gu, Alexandre Chlenski, Arlene Naranjo, Amy Gill, Radhika Peddinti, Bruce T. Lahn, Susan L. Cohn, Lucy A. Godley   +17 more
openalex   +1 more source

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

Advanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du, Yudi Ren, Qiaoqiao Meng, Peng Wei, Ruyu Zhu, Junjie Bao, Ye Yang, Shuo Yan, Chaorong Yue, Xueying Zhu, Shuo Cao, Chunxia Hao, Wei Sun, Yongli Song, Xihe Li, Zhimin Wu, Siqin Bao, Yanglin Chen   +17 more
wiley   +1 more source

Supplementary Figure Legend from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma [PDF]

, 2023
Kelly R. Ostler, Qiwei Yang, Timothy J. Looney, Li Zhang, Aparna Vasanthakumar, Yufeng Tian, Masha Kocherginsky, Stacey L. Raimondi, Jessica G. DeMaio, Helen R. Salwen, Song Gu, Alexandre Chlenski, Arlene Naranjo, Amy Gill, Radhika Peddinti, Bruce T. Lahn, Susan L. Cohn, Lucy A. Godley   +17 more
openalex   +1 more source