Results 121 to 130 of about 2,686,549 (398)

Fresh and frozen cardiac tissue are comparable in DNA methylation array β-values, but formalin-fixed, paraffin-embedded tissue may overestimate DNA methylation levels

Scientific Reports, 2023
Untreated fresh cardiac tissue is the optimal tissue material for investigating DNA methylation patterns of cardiac biology and diseases. However, fresh tissue is difficult to obtain.
Mikkel Eriksen Dupont, Stine Bøttcher Jacobsen, Steffan Noe Niikanoff Christiansen, Jacob Tfelt-Hansen, Morten Holdgaard Smerup, Jeppe Dyrberg Andersen, Niels Morling   +6 more
doaj   +1 more source

Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders [PDF]

, 2014
Anxiety disorders that are the most commonly occurring psychiatric disorders in childhood, are associated with a range of social and educational impairments and often continue into adulthood.
A Bittner, A Caspi, A Heils, AN Simmons, B Freeman, CCY Wong, D Wang, DA Cole, DHM Bodden, DR Nyholt, EL Kinnally, EL Kinnally, I Ouellet-Morin, J Belsky, J Cohen, J Piacentini, JL Hudson, JT Walkup, K Karg, K Wilhelm, KJ Lester, KN Månsson, KP Lesch, M Davies, M Van Ameringen, MB Stein, MH van Ijzendoorn, MW Coolen, N Perroud, O Doehrmann, PA Jones, R Bogdan, R Jaenisch, R Lowe, R Yehuda, RA Philibert, RM Rapee, S Cartwright-Hatton, S Sen, SC Messer, SE Taylor, SRH Beach, TC Eley, TC Eley, TH Ollendick, TM Ball, U Lueken, VL Ives-Deliperi, WK Silverman   +48 more
core   +2 more sources

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Nature Communications, 2019
Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic demethylation involving methylation loss in late-replicating partial ...
H. Jung, H. Kim, Jeong Yeon Kim, Jong-Mu Sun, J. Ahn, M. Ahn, Keunchil Park, M. Esteller, Se-Hoon Lee, J. Choi   +9 more
semanticscholar   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

Nature, 2019
Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis1–4.
Daniel N. Weinberg, Simon Papillon-Cavanagh, Haifen Chen, Yuan Yue, Xiao Chen, Kartik N Rajagopalan, Cynthia Horth, John T. McGuire, Xinjing Xu, H. Nikbakht, Agata E Lemiesz, Dylan M. Marchione, M. Marunde, Matthew J. Meiners, Marcus A. Cheek, M. Keogh, E. Bareke, Anissa Djedid, A. Harutyunyan, N. Jabado, Benjamin A Garcia, Haitao Li, C. D. Allis, J. Majewski, Chao Lu   +24 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The function of DNA methylation marks in social insects

Frontiers in Ecology and Evolution, 2016
The social arthropods are characterized by a caste-based division of labor that may be influenced by epigenetic effects. One of the most important and widely studied epigenetic mechanisms is DNA methylation.
Hongmei eLi-Byarlay, Hongmei eLi-Byarlay
doaj   +1 more source

Divergent DNA Methylation Signatures of Juvenile Seedlings, Grafts and Adult Apple Trees

Epigenomes, 2020
The vast majority of previous studies on epigenetics in plants have centered on the study of inheritance of DNA methylation patterns in annual plants. In contrast, perennial plants may have the ability to accumulate changes in DNA methylation patterns ...
Adrien Perrin, Nicolas Daccord, David Roquis, Jean-Marc Celton, Emilie Vergne, Etienne Bucher   +5 more
doaj   +1 more source

DNA Methylation Reprogramming during Mammalian Development

Genes, 2019
DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the mammalian genome that plays critical roles in chromatin structure and gene expression. In general, DNA methylation is stably maintained in somatic tissues.
Yang Zeng, Taiping Chen
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source