Results 201 to 210 of about 382,011 (287)

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

A New Complexity Layer: DNA Methylation and the Predictive Impact of Epigenetic Tests. [PDF]

Int J Mol Sci
Ladisa G, Montenegro F, Picerno A, Nigro A, Cicirelli A, Stasi A, Fiorentino M, Pontrelli P, Gesualdo L, Sallustio F.   +9 more
europepmc   +1 more source

SATB2 Mediates H3K9 Delactylation by Recruiting HDAC3 to Repress LCN2 and Inhibit Lung Tumor Growth and Metastasis

Advanced Science, EarlyView.
This study highlights the capacity for tumor suppressor SATB2 to recruit HDAC3 and catalyze histone H3K9 delactylation, thereby repress transcription of the oncogene LCN2. This novel epigenetic‐metabolic axis inhibits the growth and metastasis of non‐small cell lung cancer, delineating a new mechanistic pathway with potential therapeutic relevance ...
Ting Wen, Lihua Yang, Shuang Cai, Yunxia Liu, Jianan Fan, Peng Wu, Beibei Gao, Xiaoge Xie, Hong Sun, Sida Qin, Qiao Yi Chen   +10 more
wiley   +1 more source

DNA Methylation-Regulated ZDHHC17 Promotes the Risk of Facial Skin Aging. [PDF]

Clin Cosmet Investig Dermatol
Cai X, Li W, Shi W, Ding X, Cai Y.
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Limitations of DNA Methylation Profiling in High-Grade Gliomas: Case Series. [PDF]

Diagnostics (Basel)
Milani MN, Chen CP, Sloan L, Neil EC, Yekula A, Fitzpatrick G, Chen L.   +6 more
europepmc   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

The impact of environmental exposures on DNA methylation in the EXPANSE project. [PDF]

EBioMedicine
Vogli M, Jeong A, Yu Z, Vonk JM, Ibi D, Kronberg J, Gregor P, Maier L, Leskien M, Cirach M, Dadvand P, Mikeš O, Gruzieva O, Gehring U, Wolf K, Waldenberger M, Imboden M, Čupr P, de Hoogh K, Koppelman GH, Melén E, Pickford R, Thiering E, Standl M, Estonian Biobank Research Team, Klánová J, Vlaanderen J, Vermeulen R, Probst-Hensch N, Peters A, EXPANSE Project.   +30 more
europepmc   +1 more source

Ultrasound‐Responsive Engineered Bacteria for Targeted Cancer Therapy: Strategies, Mechanisms, and Applications

Advanced Science, EarlyView.
This review elucidates URB design strategies, including genetic and physicochemical modifications, while dissecting the synergistic mechanisms governing spatiotemporal control. It further evaluates applications in targeted drug delivery, gene modulation, and immunotherapy, finally offering perspectives on overcoming translational barriers for clinical ...
Xueyao Wang, Wenjing Xu, Yafang Lu, Huaibin Yu, Zhengbao Zha, Xijun Zhang   +5 more
wiley   +1 more source

DNA Methylation

, 2015
Alokail, Majed S., Alenad, Amal M.
openaire   +4 more sources