Results 221 to 230 of about 349,927 (269)
Some of the next articles are maybe not open access.
DNA Methylation and Carcinogenesis
Biochemistry (Moscow), 2001In the world of easy things truth is opposed to lie; in the world of complicated things one profound truth is opposed to another not less profound than the first. Neils Bohr The hypothesis of the exclusively genetic origin of cancer ("cancer is a disease of genes, a tumor without any damage to the genome does not exist") dominated in the oncology until
A V, Lichtenstein, N P, Kisseljova
openaire +2 more sources
DNA Methylation and DNA Structure
1984Novel DNA substrates, such as hemimethylated DNA, supercoiled, partially or fully relaxed DNA, either intact or UV-irradiated, have been used to study either some aspects of the mechanism of DNA methylation or some aspects of the effect of pathological and physiological DNA methylation on DNA conformation.
S, Spadari +5 more
openaire +2 more sources
Critical Reviews in Biochemistry, 1982
The DNA of higher eukaryotes contains one minor base, namely 5-methylcytosine. The distribution of this minor base between different species and different DNA fractions will be considered together with the actual sequences methylated. The properties of the enzyme responsible for DNA modification will be reviewed, particular note being paid to the ...
R. L. P. Adams +2 more
openaire +2 more sources
The DNA of higher eukaryotes contains one minor base, namely 5-methylcytosine. The distribution of this minor base between different species and different DNA fractions will be considered together with the actual sequences methylated. The properties of the enzyme responsible for DNA modification will be reviewed, particular note being paid to the ...
R. L. P. Adams +2 more
openaire +2 more sources
2010
DNA methylation is one of the most intensely studied epigenetic modifications in mammals. In normal cells, it assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by ...
Marta, Kulis, Manel, Esteller
openaire +2 more sources
DNA methylation is one of the most intensely studied epigenetic modifications in mammals. In normal cells, it assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by ...
Marta, Kulis, Manel, Esteller
openaire +2 more sources
Human Molecular Genetics, 1994
Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. The mostly descriptive nature of these studies and the fact that both hypo- and hypermethylation have been observed at various loci have made it difficult to assess whether these changes are causally involved in the transformation process or whether they reflect ...
P W, Laird, R, Jaenisch
openaire +2 more sources
Changes in the pattern of DNA methylation have been a consistent finding in cancer cells. The mostly descriptive nature of these studies and the fact that both hypo- and hypermethylation have been observed at various loci have made it difficult to assess whether these changes are causally involved in the transformation process or whether they reflect ...
P W, Laird, R, Jaenisch
openaire +2 more sources
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
5-Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a mutable site, because it can undergo spontaneous deamination to thymine. There is a repair mechanism which specifically recognises G.T mispairs, and replaces thymine with cytosine ...
R, Holliday, G W, Grigg
openaire +2 more sources
5-Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a mutable site, because it can undergo spontaneous deamination to thymine. There is a repair mechanism which specifically recognises G.T mispairs, and replaces thymine with cytosine ...
R, Holliday, G W, Grigg
openaire +2 more sources
Developmental Genetics, 1989
Article de synthese sur le role dans l'expression genique differentielle de la methylation des bases de l'ADN pendant le developpement des ...
J M, Magill, C W, Magill
openaire +2 more sources
Article de synthese sur le role dans l'expression genique differentielle de la methylation des bases de l'ADN pendant le developpement des ...
J M, Magill, C W, Magill
openaire +2 more sources
2022
Haplotyping enables the study of allele-specific events. Heterozygous variants, primarily single nucleotide variants (SNVs), enable the assignment of the paternal and maternal origin of the chromosomes and are widely employed to phase sequencing reads to their haplotype of origin.
Vahid, Akbari, Steven J M, Jones
openaire +2 more sources
Haplotyping enables the study of allele-specific events. Heterozygous variants, primarily single nucleotide variants (SNVs), enable the assignment of the paternal and maternal origin of the chromosomes and are widely employed to phase sequencing reads to their haplotype of origin.
Vahid, Akbari, Steven J M, Jones
openaire +2 more sources
Journal of Cellular Physiology, 2000
The methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The enzyme involved in this process is DNA methyltransferase, which catalyzes the transfer of a methyl group from S-adenosyl-methionine to cytosine residues to form 5-methylcytosine, a modified base that is found ...
R L, Momparler, V, Bovenzi
openaire +2 more sources
The methylation of DNA is an epigenetic modification that can play an important role in the control of gene expression in mammalian cells. The enzyme involved in this process is DNA methyltransferase, which catalyzes the transfer of a methyl group from S-adenosyl-methionine to cytosine residues to form 5-methylcytosine, a modified base that is found ...
R L, Momparler, V, Bovenzi
openaire +2 more sources
2012
Cancer has been considered a genetic disease with a wide array of well-characterized gene mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have been elucidated in cancer, and together with genetic alterations, they have been helpful in understanding the complex traits observed in neoplasia.
Gopinathan, Gokul, Sanjeev, Khosla
openaire +2 more sources
Cancer has been considered a genetic disease with a wide array of well-characterized gene mutations and chromosomal abnormalities. Of late, aberrant epigenetic modifications have been elucidated in cancer, and together with genetic alterations, they have been helpful in understanding the complex traits observed in neoplasia.
Gopinathan, Gokul, Sanjeev, Khosla
openaire +2 more sources