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Orchestration of DNA Methylation
2008DNA methylation plays an important role in gene regulation. In order to gain a better understanding of the rules governing this epigenetic modification, we have used microarray technology to map DNA methylation in the human genome. This analysis has helped decipher the DNA sequences involved in setting up the basic global methylation pattern in the ...
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Annual Review of Plant Physiology and Plant Molecular Biology, 1998
▪ Abstract  Methylation of cytosine residues in DNA provides a mechanism of gene control. There are two classes of methyltransferase in Arabidopsis; one has a carboxy-terminal methyltransferase domain fused to an amino-terminal regulatory domain and is similar to mammalian methyltransferases.
E. J., Finnegan +3 more
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▪ Abstract  Methylation of cytosine residues in DNA provides a mechanism of gene control. There are two classes of methyltransferase in Arabidopsis; one has a carboxy-terminal methyltransferase domain fused to an amino-terminal regulatory domain and is similar to mammalian methyltransferases.
E. J., Finnegan +3 more
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Human Genetics, 1983
Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base.5mC arises by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in the dinucleotide CpG. The base is not distributed randomly in these genomes but conforms to a pattern. This pattern varies between taxa but appears to be inherited in a semi-conservative
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Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base.5mC arises by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in the dinucleotide CpG. The base is not distributed randomly in these genomes but conforms to a pattern. This pattern varies between taxa but appears to be inherited in a semi-conservative
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2010
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer.
Yoshihisa, Watanabe, Masato, Maekawa
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Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Global changes in the epigenetic landscape are a hallmark of cancer.
Yoshihisa, Watanabe, Masato, Maekawa
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DNA Methylation and Epigenotypes
Biochemistry (Moscow), 2005The science of epigenetics is the study of all those mechanisms that control the unfolding of the genetic program for development and determine the phenotypes of differentiated cells. The pattern of gene expression in each of these cells is called the epigenotype. The best known and most thoroughly studied epigenetic mechanism is DNA methylation, which
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1984
The interrelationship between sister chromatid exchange (SCE) formation and DNA methylation was studied in Chinese hamster V79 and Indian muntjac cells. A DNA methylation inhibitor, 5-azacytidine (5AzaC), induced SCEs only when it had been present in cells for at least 2 rounds of DNA replication.
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The interrelationship between sister chromatid exchange (SCE) formation and DNA methylation was studied in Chinese hamster V79 and Indian muntjac cells. A DNA methylation inhibitor, 5-azacytidine (5AzaC), induced SCEs only when it had been present in cells for at least 2 rounds of DNA replication.
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Current Opinion in Genetics & Development, 1995
Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation
R A, Martienssen, E J, Richards
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Recent advances have expanded our understanding of the processes underlying the establishment, maintenance, and elaboration of DNA methylation patterns in eukaryotes. The functional significance of DNA methylation is sought in a comparison of results on a variety of epigenetic phenomena in different eukaryotes. The recent development of DNA methylation
R A, Martienssen, E J, Richards
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Annals of the New York Academy of Sciences, 2004
Abstract: Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer.
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Abstract: Early detection of cancer would facilitate better management of patients, because survival is greatly affected by stage of presentation. Circulating nucleic acids represent a biomarker that might be used in the early detection of cancer. In addition, such biomarkers could potentially be used to follow the progression of patients with cancer.
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Methyl DNA Immunoprecipitation
2009Epigenetics is the study of heritable changes in gene expression. Chromatin immunoprecipitation (ChIP) and methylation status analysis of genes have been applied to the study of epigenetic modifications, often perturbed in human cancer. ChIP is a technique allowing the analysis of the protein association with specific genomic regions in the context of ...
Juana, Magdalena, Jean-Jacques, Goval
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