Results 251 to 260 of about 620,119 (303)
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Cancer Prevention Research, 2009
Abstract This perspective on Candiloro and Dobrovic (beginning on p. 862 in this issue of the journal) highlights the interplay between epigenetic aberrations and underlying DNA sequence changes and illustrates how these alterations may predispose individuals to cancer.
Hitchins, Megan P., Ward, Robyn L.
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Abstract This perspective on Candiloro and Dobrovic (beginning on p. 862 in this issue of the journal) highlights the interplay between epigenetic aberrations and underlying DNA sequence changes and illustrates how these alterations may predispose individuals to cancer.
Hitchins, Megan P., Ward, Robyn L.
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Biochemical and Biophysical Research Communications, 1983
The lower amount of 5 methylcytosine in DNA from bull sperm relative to DNA of other bovine tissues is a result of the absence of this minor base from several of the satellite DNAs in sperm. This applies particularly to the 1.715, 1.711b and 1.709 satellites and less so to the 1.706 and 1.711a satellites.
R L, Adams, R H, Burdon, J, Fulton
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The lower amount of 5 methylcytosine in DNA from bull sperm relative to DNA of other bovine tissues is a result of the absence of this minor base from several of the satellite DNAs in sperm. This applies particularly to the 1.715, 1.711b and 1.709 satellites and less so to the 1.706 and 1.711a satellites.
R L, Adams, R H, Burdon, J, Fulton
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2023
DNA methylation of promoter CpG islands silences their downstream genes, and enhancer methylation can be associated with decreased or increased gene expression. DNA methylation alterations in normal and diseased cells provide rich information, such as tissue origin, disease risk, patient response, and prognosis.
Naoko, Hattori +2 more
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DNA methylation of promoter CpG islands silences their downstream genes, and enhancer methylation can be associated with decreased or increased gene expression. DNA methylation alterations in normal and diseased cells provide rich information, such as tissue origin, disease risk, patient response, and prognosis.
Naoko, Hattori +2 more
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Gene, 1988
Both replicative and postreplicative nuclear DNA (nDNA) methylation, with the formation of 5-methylcytosine (mC) residues, occurs in plants. These two types of enzymatic DNA modification are different in amount and nucleotide sequence of methylatable sites, as well as in sensitivity to phytohormones, temperature and various inhibitors of DNA ...
B F, Vanyushin, M D, Kirnos
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Both replicative and postreplicative nuclear DNA (nDNA) methylation, with the formation of 5-methylcytosine (mC) residues, occurs in plants. These two types of enzymatic DNA modification are different in amount and nucleotide sequence of methylatable sites, as well as in sensitivity to phytohormones, temperature and various inhibitors of DNA ...
B F, Vanyushin, M D, Kirnos
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
5-Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a mutable site, because it can undergo spontaneous deamination to thymine. There is a repair mechanism which specifically recognises G.T mispairs, and replaces thymine with cytosine ...
R, Holliday, G W, Grigg
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5-Methylcytosine (5mC) in DNA is produced by post-synthetic modification of cytosine residues, and it occurs primarily in CpG doublets in the mammalian genome. 5mC is a mutable site, because it can undergo spontaneous deamination to thymine. There is a repair mechanism which specifically recognises G.T mispairs, and replaces thymine with cytosine ...
R, Holliday, G W, Grigg
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DNA Methylation and DNA Structure
1984Novel DNA substrates, such as hemimethylated DNA, supercoiled, partially or fully relaxed DNA, either intact or UV-irradiated, have been used to study either some aspects of the mechanism of DNA methylation or some aspects of the effect of pathological and physiological DNA methylation on DNA conformation.
S, Spadari +5 more
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Developmental Genetics, 1989
Article de synthese sur le role dans l'expression genique differentielle de la methylation des bases de l'ADN pendant le developpement des ...
J M, Magill, C W, Magill
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Article de synthese sur le role dans l'expression genique differentielle de la methylation des bases de l'ADN pendant le developpement des ...
J M, Magill, C W, Magill
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DNA Methylation and Carcinogenesis
Biochemistry (Moscow), 2001In the world of easy things truth is opposed to lie; in the world of complicated things one profound truth is opposed to another not less profound than the first. Neils Bohr The hypothesis of the exclusively genetic origin of cancer ("cancer is a disease of genes, a tumor without any damage to the genome does not exist") dominated in the oncology until
A V, Lichtenstein, N P, Kisseljova
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2010
DNA methylation is one of the most intensely studied epigenetic modifications in mammals. In normal cells, it assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by ...
Marta, Kulis, Manel, Esteller
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DNA methylation is one of the most intensely studied epigenetic modifications in mammals. In normal cells, it assures the proper regulation of gene expression and stable gene silencing. DNA methylation is associated with histone modifications and the interplay of these epigenetic modifications is crucial to regulate the functioning of the genome by ...
Marta, Kulis, Manel, Esteller
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