Results 201 to 210 of about 620,119 (303)

Associations of rDNA copy numbers and global DNA methylation with myocardial infarction. [PDF]

Front Cardiovasc Med
Wang X, Memon AA, Hedelius A, Grundberg A, Sundquist K.   +4 more
europepmc   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Quantification of DNA Methylation for Diagnosis and Monitoring of Hepatocellular Carcinoma. [PDF]

J Am Coll Surg
Javanshir S, Angeli-Pahim I, Iyengar P, Chambers A, Smarandache IM, Ganguli R, Hughes S, Sahin I, Duarte S, Zarrinpar A.   +9 more
europepmc   +1 more source

Ligand‐Defined Interfacial Chemistry Enables Instant and Sequence‐General DNA Chemisorption on Gold Nanoparticles Toward Label‐Free SERS With Single‐Base Resolution

Advanced Science, EarlyView.
Ascorbic Acid‐Engineered Interface Enables Universal DNA Functionalization on Gold Nanoparticles: Attenuating electrostatic repulsion and leveraging synergistic hydrogen‐bonding interactions significantly lowers the kinetic barrier for DNA adsorption, enabling rapid and sequence‐general functionalization of non‐thiolated DNA‐requiring only a single ...
Guangping Li, Cheng Wang, Xinyue Wu, Zhongxiang Ding, Heng Gao, Zhonggang Liu, Yu Zhang, Jinai Chen, Feng Wang, Honglin Liu   +9 more
wiley   +1 more source

Establishment of DNA methylation during primate germ cell development. [PDF]

Nat Commun
Kojima K, Li Y, Tomizawa SI, Kohara M, Kuze Y, Sato T, Ebata T, Kubiura-Ichimaru M, Cao M, Hattori T, Maezawa S, Winge SB, Almstrup K, Nakaki R, Sato S, Miyagi Y, Daigo Y, Yoshioka T, Hasegawa Y, Kinoshita Y, Hyuga T, Moriya K, Kobayashi H, Baskin L, Sankai T, Watanabe T.   +25 more
europepmc   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

Advanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li, Xijia Wang, Yaning Hu, Zhen Yang, Tian Niu, Xingbo Zhao   +5 more
wiley   +1 more source

Editing DNA methylation in vivo. [PDF]

Nat Commun
Pan R, Ren J, Chen X, Flores LF, Gonzalez RVL, Adonnino AA, Lofts B, Waldo J, Halmai J, Devinsky O, Fink K, Liu XS.   +11 more
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

DNA Methylation Dynamics in Development and Disease: Insights from Zebrafish Models. [PDF]

Biomedicines
Lai GQ, Yan Y, Sengupta M, Xu TH.
europepmc   +1 more source