Results 311 to 320 of about 2,729,754 (384)

Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis

Advanced Science, EarlyView.
In this study, it is discovered that pathological accumulation of Runx2+ Schwann cell clusters​ during axonal regeneration is a key factor impairing nerve repair in aging. This pathology is associated with ​dysregulation of stress granule homeostasis.
Peilin Wang, Renyuan Wang, Yilin Huo, Ying Peng, Chuanliang Fu, Yi Hu, Zun Ren, Yersen Mulat, Hao Zhang, Dongsheng Jiang, Haodong Lin   +10 more
wiley   +1 more source

Advancements in DNA methylation technologies and their application in cancer diagnosis. [PDF]

Epigenetics
Yang Y, Wen X, Wang L.
europepmc   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Comparison of current methods for genome-wide DNA methylation profiling. [PDF]

Epigenetics Chromatin
de Abreu AR, Ibrahim J, Lemonidis V, Mateiu L, Van Camp G, Op de Beeck K.   +5 more
europepmc   +1 more source

Marker Metabolite‐Based Multi‐Omics Analysis Identifies New Loci Controlling Thousand Seed Weight in Brassica Napus

Advanced Science, EarlyView.
Marker metabolite‐based multi‐omics (genome, transcriptome, and metabolome) analysis is conducted firstly to unravel the genetic basis of thousand seed weight (TSW) in Brassica napus. The released metabolite‐QTL‐gene network represents a valuable genetic resource, and the newly validated BnaTGA6 is a promising target for the improvement of TSW in ...
Long Li, Zhitao Tian, Xiaowei Wu, Zengdong Tan, Xu Han, Yuyan Xiang, Jie Chen, Hu Zhao, Wei Chen, Liang Guo, Xuan Yao   +10 more
wiley   +1 more source

DNA methylation and machine learning: challenges and perspective toward enhanced clinical diagnostics. [PDF]

Clin Epigenetics
Aref-Eshghi E, Abadi AB, Farhadieh ME, Hooshmand A, Ghasemi F, Youssefian L, Vahidnezhad H, Kerrins TM, Zhao X, Akbarzadeh M, Hakonarson H, Saeidian AH.   +11 more
europepmc   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

The Role of NOL3 in Colon Adenocarcinoma Metastasis and Its Association With DNA Methylation. [PDF]

Hum Mutat
Hong L, Zhang H, Wang R, Zhuang Z, Xu J, Tang Y.   +5 more
europepmc   +1 more source

Distinct Phage‐Encoded Enzymes for Substitution of Deoxythymidine by Deoxyuridine in Phage Genomes

Advanced Science, EarlyView.
Distinct enzymes including dCTP deaminases (Dcds), dTMP phosphatases (Dtms), and dTTP pyrophosphatases (Dtt) are found to be responsible for dU‐DNA biosynthesis in the phages PBS1, DSS3_VP1, and PhiR1‐37. Both PhiR1‐37‐derived and synthetic dU‐DNA are resistant to cleavage by restriction enzymes and Cas12a nuclease targeting dT‐containing sites.
Yating Li, Jason Tan, Yanqin Tu, Jingnan Wu, Zaifang Zhang, Yifeng Wei, Xinan Jiao, Yan Zhou   +7 more
wiley   +1 more source

DNA Methylation: A Potential Mediator of the Memory Regulatory Effects of taVNS. [PDF]

Cells
Yee POP, Tsui KC, Fung ML, Heng BC, Kocabicak E, Jahanshahi A, Temel Y, Blokland A, Aquili L, Kalueff A, Wong KH, Lim LW.   +11 more
europepmc   +1 more source