Results 81 to 90 of about 2,686,549 (398)

Regulated DNA Methylation and the Circadian Clock: Implications in Cancer

Biology, 2014
Since the cloning and discovery of DNA methyltransferases (DNMT), there has been a growing interest in DNA methylation, its role as an epigenetic modification, how it is established and removed, along with the implications in development and disease.
Tammy M. Joska, Riasat Zaman, William J. Belden   +2 more
doaj   +1 more source

Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood. [PDF]

, 2019
A growing body of research has documented associations between adverse childhood environments and DNA methylation, highlighting epigenetic processes as potential mechanisms through which early external contexts influence health across the life course ...
Boyce, W Thomas, Bush, Nicole R, Emberly, Eldon, Essex, Marilyn J, Farré, Pau, Goodman, Sarah J, Hertzman, Clyde, Kobor, Michael S, Park, Mina, Roubinov, Danielle S   +9 more
core   +1 more source

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Nature Communications, 2018
Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions.
Stephen J. Clark, R. Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, G. Sanguinetti, G. Kelsey, J. Marioni, O. Stegle, W. Reik   +11 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

DNA Methylation Cancer Biomarkers: Translation to the Clinic

Frontiers in Genetics, 2019
Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with focal hypermethylation of numerous 5’-cytosine-phosphate-guanine-3’ (CpG) islands, often ...
Warwick J. Locke, Dominic Guanzon, Chenkai Ma, Y. Liew, Konsta Duesing, K. Fung, Jason Ross   +6 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation. [PDF]

PLoS ONE, 2015
In mammals, DNA methylation plays important roles in embryogenesis and terminal differentiation via regulation of the transcription-competent chromatin state.
Ronald Garingalao Garvilles, Takashi Hasegawa, Hironobu Kimura, Jafar Sharif, Masahiro Muto, Haruhiko Koseki, Saori Takahashi, Isao Suetake, Shoji Tajima   +8 more
doaj   +1 more source

Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]

, 2014
Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation.
Capra, John A., Kostka, Dennis
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles

Genome Biology, 2012
DNA methylation is a chemical modification of cytosine bases that is pivotal for gene regulation,cellular specification and cancer development. Here, we describe an R package, methylKit, thatrapidly analyzes genome-wide cytosine epigenetic profiles from ...
A. Akalin, Matthias Kormaksson, Sheng Li, Francine E. Garrett-Bakelman, M. Figueroa, A. Melnick, C. Mason   +6 more
semanticscholar   +1 more source