Results 1 to 10 of about 2,563,210 (334)

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

open access: yesAdvanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji   +14 more
wiley   +1 more source

Development of DNA Microarray for Parallel Detection of Community-Acquired Pneumonia Bacterial Pathogens. [PDF]

open access: yesSovrem Tekhnologii Med
Sakharnov NA   +4 more
europepmc   +1 more source

Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray

open access: green, 2001
Marianne D. De Backer   +5 more
openalex   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang   +28 more
wiley   +1 more source

Fabrication of DNA Microarrays Using Unmodified Oligonucleotide Probes

open access: gold, 2001
Douglas R. Call   +2 more
openalex   +1 more source

DNA microarrays to study gene expression profiles in testis of fertile and infertile men. [PDF]

open access: bronze, 2001
Pasquale Patrizio   +4 more
openalex   +1 more source

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