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Nucleic acid - protein fingerprints. Novel protein classification based on nucleic acid - protein recognition [PDF]
, 2012 Protein chemistry uses protein description and classification based on molecular mass and isoelectric point as general features. Enzymes are also compared by enzymatic reaction constants, namely Km and kcat values. Proteins are also studied by binding to
Alexander Krylov, Renad Zhdanov
core +1 more source
Performance evaluation of DNA copy number segmentation methods [PDF]
Briefings in Bioinformatics, Oxford University Press (OUP), 2015,
16 (4), 2014 A number of bioinformatic or biostatistical methods are available for analyzing DNA copy number profiles measured from microarray or sequencing technologies. In the absence of rich enough gold standard data sets, the performance of these methods is generally assessed using unrealistic simulation studies, or based on small real data analyses.
arxiv +1 more source
Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. [PDF]
, 2006 A pan-viral DNA microarray, the Virochip (University of California, San Francisco), was used to detect human parainfluenzavirus 4 (HPIV-4) infection in an immunocompetent adult presenting with a life-threatening acute respiratory illness.
Blackburn, Brian G +13 more
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Nonequilibrium effects in DNA microarrays: a multiplatform study [PDF]
J. Phys. Chem. B, 2011, 115 (20), pp 6732--6739, 2011 It has recently been shown that in some DNA microarrays the time needed to reach thermal equilibrium may largely exceed the typical experimental time, which is about 15h in standard protocols (Hooyberghs et al. Phys. Rev. E 81, 012901 (2010)). In this paper we discuss how this breakdown of thermodynamic equilibrium could be detected in microarray ...
arxiv +1 more source
ArrayQuest: a web resource for the analysis of DNA microarray data
BMC Bioinformatics, 2005 Background Numerous microarray analysis programs have been created through the efforts of Open Source software development projects. Providing browser-based interfaces that allow these programs to be executed over the Internet enhances the applicability ...
Barth Jeremy L +3 more
doaj +1 more source
Disease Models & Mechanisms, 2011 SUMMARY Brain ischemia, also termed cerebral ischemia, is a condition in which there is insufficient blood flow to the brain to meet metabolic demand, leading to tissue death (cerebral infarction) due to poor oxygen supply (cerebral hypoxia).
M. Hori +9 more
semanticscholar +1 more source
Sultan Qaboos University Medical Journal, 2013 Objectives: The aim of this study was to develop and validate a comparative genomic hybridisation (CGH) array that would allow simultaneous targeted analysis of a panel of disease genes and low resolution whole genome analysis.
Renate Marquis-Nicholson +6 more
doaj
Molecules, 2003 We present a novel method for fabricating unimole cular double-stranded DNA microarrays on solid surfaces, which were used to probe sequence-specific DNA/protein interactions.
Zuhong Lu +4 more
doaj +1 more source
Statistical modelling of transcript profiles of differentially regulated genes [PDF]
, 2008 Background: The vast quantities of gene expression profiling data produced in microarray studies, and the more precise quantitative PCR, are often not statistically analysed to their full potential.
Burton, Kerry S. +3 more
core +4 more sources
Thermodynamics of RNA/DNA hybridization in high density oligonucleotide microarrays [PDF]
Physica A 362, 433 (2006), 2004 We analyze a series of publicly available controlled experiments (Latin square) on Affymetrix high density oligonucleotide microarrays using a simple physical model of the hybridization process. We plot for each gene the signal intensity versus the hybridization free energy of RNA/DNA duplexes in solution, for perfect matching and mismatching probes ...
arxiv +1 more source